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Volumetric capnography and return of spontaneous circulation in an experimental model of pediatric asphyxial cardiac arrest.
de la Mata Navazo, Sara; Manrique, Gema; Fernández, Sarah Nicole; Pérez, Gema; Butragueño-Laiseca, Laura; García, Miriam; Slöcker, María; González, Rafael; Herrera, Laura; Mencía, Santiago; Del Castillo, Jimena; Solana, María José; Sanz, Débora; Cieza, Raquel; López, Jorge; Rodríguez Martínez, Alicia; Santiago, María José; Urbano, Javier; López-Herce, Jesús.
Afiliación
  • de la Mata Navazo S; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain.
  • Manrique G; Health Research Institute of the Gregorio Marañón Hospital, Madrid, Spain.
  • Fernández SN; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21/0012/0011, Carlos III Health Institute, Madrid, Spain.
  • Pérez G; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain. gema_manrique@hotmail.com.
  • Butragueño-Laiseca L; Health Research Institute of the Gregorio Marañón Hospital, Madrid, Spain. gema_manrique@hotmail.com.
  • García M; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21/0012/0011, Carlos III Health Institute, Madrid, Spain. gema_manrique@hotmail.com.
  • Slöcker M; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain.
  • González R; Health Research Institute of the Gregorio Marañón Hospital, Madrid, Spain.
  • Herrera L; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21/0012/0011, Carlos III Health Institute, Madrid, Spain.
  • Mencía S; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain.
  • Del Castillo J; Health Research Institute of the Gregorio Marañón Hospital, Madrid, Spain.
  • Solana MJ; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21/0012/0011, Carlos III Health Institute, Madrid, Spain.
  • Sanz D; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain.
  • Cieza R; Health Research Institute of the Gregorio Marañón Hospital, Madrid, Spain.
  • López J; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21/0012/0011, Carlos III Health Institute, Madrid, Spain.
  • Rodríguez Martínez A; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain.
  • Santiago MJ; Health Research Institute of the Gregorio Marañón Hospital, Madrid, Spain.
  • Urbano J; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Development Origin Network (RICORS) RD21/0012/0011, Carlos III Health Institute, Madrid, Spain.
  • López-Herce J; Pediatric Intensive Care Department, Gregorio Marañón University Hospital, Dr Castelo 47, 28009, Madrid, Spain.
Sci Rep ; 13(1): 12247, 2023 07 28.
Article en En | MEDLINE | ID: mdl-37507472
A secondary analysis of a randomized study was performed to study the relationship between volumetric capnography (VCAP) and arterial CO2 partial pressure (PCO2) during cardiopulmonary resuscitation (CPR) and to analyze the ability of these parameters to predict the return of spontaneous circulation (ROSC) in a pediatric animal model of asphyxial cardiac arrest (CA). Asphyxial CA was induced by sedation, muscle relaxation and extubation. CPR was started 2 min after CA occurred. Airway management was performed with early endotracheal intubation or bag-mask ventilation, according to randomization group. CPR was continued until ROSC or 24 min of resuscitation. End-tidal carbon dioxide (EtCO2), CO2 production (VCO2), and EtCO2/VCO2/kg ratio were continuously recorded. Seventy-nine piglets were included, 26 (32.9%) of whom achieved ROSC. EtCO2 was the best predictor of ROSC (AUC 0.72, p < 0.01 and optimal cutoff point of 21.6 mmHg). No statistical differences were obtained regarding VCO2, VCO2/kg and EtCO2/VCO2/kg ratios. VCO2 and VCO2/kg showed an inverse correlation with PCO2, with a higher correlation coefficient as resuscitation progressed. EtCO2 also had an inverse correlation with PCO2 from minute 18 to 24 of resuscitation. Our findings suggest that EtCO2 is the best VCAP-derived parameter for predicting ROSC. EtCO2 and VCO2 showed an inverse correlation with PCO2. Therefore, these parameters are not adequate to measure ventilation during CPR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reanimación Cardiopulmonar / Paro Cardíaco Extrahospitalario / Paro Cardíaco Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reanimación Cardiopulmonar / Paro Cardíaco Extrahospitalario / Paro Cardíaco Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido