Molecular cell types as functional units of the efferent vagus nerve.

Coverdell, Tatiana C; Abbott, Stephen B G; Campbell, John N

Coverdell, Tatiana C; Abbott, Stephen B G; Campbell, John N.

Afiliación

Coverdell TC; Biomedical Sciences Graduate Program, University of Virginia, Charlottesville, VA 22903, USA.
Abbott SBG; Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
Campbell JN; Department of Biology, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: jnc4e@virginia.edu.

Semin Cell Dev Biol ; 156: 210-218, 2024 03 15.

Article en En | MEDLINE | ID: mdl-37507330

ABSTRACT

ABSTRACT

The vagus nerve vitally connects the brain and body to coordinate digestive, cardiorespiratory, and immune functions. Its efferent neurons, which project their axons from the brainstem to the viscera, are thought to comprise "functional units" - neuron populations dedicated to the control of specific vagal reflexes or organ functions. Previous research indicates that these functional units differ from one another anatomically, neurochemically, and physiologically but have yet to define their identity in an experimentally tractable way. However, recent work with genetic technology and single-cell genomics suggests that genetically distinct subtypes of neurons may be the functional units of the efferent vagus. Here we review how these approaches are revealing the organizational principles of the efferent vagus in unprecedented detail.

Asunto(s)

Neuronas Eferentes; Nervio Vago; Nervio Vago/metabolismo; Neuronas/fisiología

Palabras clave

Dorsal motor nucleus of the vagus; Nucleus ambiguus; Parasympathetic preganglionic; Tenth cranial nerve; Vagal motor neuron

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Vago / Neuronas Eferentes Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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