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Symptoms and symptom clusters in patients newly diagnosed with inflammatory bowel disease: results from the IBSEN III Study.
Johansen, Ingunn; Småstuen, Milada Cvancarova; Løkkeberg, Stine Torp; Kristensen, Vendel Ailin; Høivik, Marte Lie; Lund, Charlotte; Olsen, Bjørn; Strande, Vibeke; Huppertz-Hauss, Gert; Aabrekk, Tone Bergene; Bengtson, May-Bente; Ricanek, Petr; Detlie, Trond Espen; Frigstad, Svein Oskar; Jelsness-Jørgensen, Lars-Petter; Opheim, Randi.
Afiliación
  • Johansen I; Department of Health, Welfare and Organization, Østfold University College, Fredrikstad, Norway. Ingunn.johansen@hiof.no.
  • Småstuen MC; Institute of Health and Society, University of Oslo, Oslo, Norway. Ingunn.johansen@hiof.no.
  • Løkkeberg ST; Department of Health Science, Oslo Metropolitan University, Oslo, Norway.
  • Kristensen VA; Department of Health, Welfare and Organization, Østfold University College, Fredrikstad, Norway.
  • Høivik ML; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
  • Lund C; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
  • Olsen B; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Strande V; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
  • Huppertz-Hauss G; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Aabrekk TB; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Bengtson MB; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway.
  • Ricanek P; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Detlie TE; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
  • Frigstad SO; Department of Gastroenterology, Lovisenberg Diaconal Hospital, Oslo, Norway.
  • Jelsness-Jørgensen LP; Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway.
  • Opheim R; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
BMC Gastroenterol ; 23(1): 255, 2023 Jul 27.
Article en En | MEDLINE | ID: mdl-37501083
BACKGROUND: Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine the prevalence of symptoms and explore symptom clusters and possible associations between symptom clusters and socio-demographic and clinical variables in patients newly diagnosed with inflammatory bowel disease. METHODS: The IBSEN III study is a prospective population-based inception cohort of patients with inflammatory bowel disease. This study used patient data from the three largest hospitals in the study catchment area. The Memorial Symptom Assessment Scale was used to assess the prevalence of symptoms. Symptom clusters were identified using principal component analysis. Possible associations between socio-demographic and clinical variables and symptom cluster membership were estimated using regression analysis. RESULTS: Of the 573 patients (age, ≥18 years) diagnosed with inflammatory bowel disease, 350 (61.1%) completed the questionnaire (responders). Eleven symptoms were reported by >50% of the responders. The three most prevalent symptoms were bloating (84%), drowsiness (81%), and lack of energy (81%). Three symptom clusters were identified: psychological (56% of the patients), impaired energy (28%), and physical (16%) clusters. Multinomial regression analysis revealed that vitamin D deficiency was significantly associated with the impaired energy cluster (odds ratio=2.49, 95% confidence interval [1.00-6.2], p=0.05). CONCLUSIONS: We found high symptom prevalence in patients newly diagnosed with inflammatory bowel disease. Three distinct symptom clusters were identified, and the psychological cluster includes >50% of the patients. Vitamin D deficiency is the only factor associated with cluster membership, namely the impaired energy cluster.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido