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Association between physical activity and episodic memory and the moderating effects of the apolipoprotein E ε4 allele and age.
Lee, Boung Chul; Choe, Young Min; Suh, Guk-Hee; Choi, Ihn-Geun; Kim, Hyun Soo; Hwang, Jaeuk; Yi, Dahyun; Kim, Jee Wook.
Afiliación
  • Lee BC; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea.
  • Choe YM; Department of Neuropsychiatry, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea.
  • Suh GH; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea.
  • Choi IG; Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi, Republic of Korea.
  • Kim HS; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea.
  • Hwang J; Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Gyeonggi, Republic of Korea.
  • Yi D; Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea.
  • Kim JW; Department of Psychiatry, Seoul W Psychiatric Office, Seoul, Republic of Korea.
Front Aging Neurosci ; 15: 1184609, 2023.
Article en En | MEDLINE | ID: mdl-37496755
Background: An abundance of evidence indicates that physical activity may protect against Alzheimer's disease (AD) and related cognitive decline. However, little is known about the association between physical activity and AD-related cognitive decline according to age and the apolipoprotein E (APOE) ε4 allele (APOE4) as major risk factors. Therefore, we examined whether age and APOE4 status modulate the effects of physical activity on episodic memory as AD-related cognition in non-demented older adults. Methods: We enrolled 196 adults aged between 65 and 90 years, with no dementia. All participants underwent comprehensive clinical assessments including physical activity evaluation and APOE genotyping. The AD-related cognitive domain was assessed by the episodic memory, as the earliest cognitive change in AD, and non-memory cognition for comparative purposes. Overall cognition was assessed by the total score (TS) of the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery. Results: We found significant physical activity × age and physical activity × APOE4 interaction effects on episodic memory. Subgroup analyses indicated that an association between physical activity and increased episodic memory was apparent only in subjects aged > 70 years, and in APOE4-positive subjects. Conclusion: Our findings suggest that physical activity has beneficial effects on episodic memory, as an AD-related cognitive domain, in individuals aged > 70 years and in APOE4-positive individuals. Physicians should take age and APOE4 status account into when recommending physical activity to prevent AD-related cognitive decline.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2023 Tipo del documento: Article Pais de publicación: Suiza