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Social memory in female mice is rapidly modulated by 17ß-estradiol through ERK and Akt modulation of synapse formation.
Sheppard, Paul A S; Chandramohan, Deepthi; Lumsden, Alanna; Vellone, Daniella; Denley, Matthew C S; Srivastava, Deepak P; Choleris, Elena.
Afiliación
  • Sheppard PAS; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • Chandramohan D; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London WC2R 2LS, United Kingdom.
  • Lumsden A; Medical Research Council Centre for Neurodevelopmental Disorders, King's College London, London WC2R 2LS, United Kingdom.
  • Vellone D; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • Denley MCS; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, Canada.
  • Srivastava DP; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London WC2R 2LS, United Kingdom.
  • Choleris E; Medical Research Council Centre for Neurodevelopmental Disorders, King's College London, London WC2R 2LS, United Kingdom.
Proc Natl Acad Sci U S A ; 120(31): e2300191120, 2023 08.
Article en En | MEDLINE | ID: mdl-37490537
Social memory is essential to the functioning of a social animal within a group. Estrogens can affect social memory too quickly for classical genomic mechanisms. Previously, 17ß-estradiol (E2) rapidly facilitated short-term social memory and increased nascent synapse formation, these synapses being potentiated following neuronal activity. However, what mechanisms underlie and coordinate the rapid facilitation of social memory and synaptogenesis are unclear. Here, the necessity of extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K) signaling for rapid facilitation of short-term social memory and synaptogenesis was tested. Mice performed a short-term social memory task or were used as task-naïve controls. ERK and PI3K pathway inhibitors were infused intradorsal hippocampally 5 min before E2 infusion. Forty minutes following intrahippocampal E2 or vehicle administration, tissues were collected for quantification of glutamatergic synapse number in the CA1. Dorsal hippocampal E2 rapid facilitation of short-term social memory depended upon ERK and PI3K pathways. E2 increased glutamatergic synapse number (bassoon puncta positive for GluA1) in task-performing mice but decreased synapse number in task-naïve mice. Critically, ERK signaling was required for synapse formation/elimination in task-performing and task-naïve mice, whereas PI3K inhibition blocked synapse formation only in task-performing mice. While ERK and PI3K are both required for E2 facilitation of short-term social memory and synapse formation, only ERK is required for synapse elimination. This demonstrates previously unknown, bidirectional, rapid actions of E2 on brain and behavior and underscores the importance of estrogen signaling in the brain to social behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Quinasas MAP Reguladas por Señal Extracelular Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Quinasas MAP Reguladas por Señal Extracelular Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos