Reactive intermediates formation and bioactivation pathways of spebrutinib revealed by LC-MS/MS: <i>In vitro</i> and <i>in silico</i> metabolic study.

Alsibaee, Aishah M; Aljohar, Haya I; Attwa, Mohamed W; Abdelhameed, Ali Saber; Kadi, Adnan A

Reactive intermediates formation and bioactivation pathways of spebrutinib revealed by LC-MS/MS: In vitro and in silico metabolic study.

Alsibaee, Aishah M; Aljohar, Haya I; Attwa, Mohamed W; Abdelhameed, Ali Saber; Kadi, Adnan A.

Afiliación

Alsibaee AM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Aljohar HI; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Attwa MW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdelhameed AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Kadi AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Heliyon ; 9(6): e17058, 2023 Jun.

Article en En | MEDLINE | ID: mdl-37484253

Palabras clave

Bruton tyrosine kinase inhibitor; DEREK; LC-MS/MS; Metabolism; Reactive intermediates; Spebrutinib; StarDrop WhichP450™ module; Trapping agents

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google