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Pain and Itch Processing in Aged Mice.
Braz, João M; Hamel, Katherine; Craik, Veronica; Rodriguez-Rosado, Sian; Bhardwaj, Karnika; Jewell, Madison; Bieri, Gregor; Villeda, Saul A; Basbaum, Allan I.
Afiliación
  • Braz JM; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Hamel K; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Craik V; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Rodriguez-Rosado S; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Bhardwaj K; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Jewell M; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Bieri G; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Villeda SA; Department of Anatomy, University of California, San Francisco, San Francisco, California.
  • Basbaum AI; Department of Anatomy, University of California, San Francisco, San Francisco, California.
J Pain ; 25(1): 53-63, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37482234
ABSTRACT
Most reports agree that aging negatively impacts pain processing and that the prevalence of chronic pain increases significantly with age. To improve current therapies, it is critical that aged animals be included in preclinical studies. Here we compared sensitivities to pain and itch-provoking stimuli in naïve and injured young and aged mice. Surprisingly, we found that in the absence of injury, aged male and female mice are significantly less responsive to mechanical stimuli and, in females, also to noxious thermal (heat) stimuli. In both older male and female mice, compared to younger (6-month-old mice), we also recorded reduced pruritogen-evoked scratching. On the other hand, after nerve injury, aged mice nevertheless developed significant mechanical hypersensitivity. Interestingly, however, and in contrast to young mice, aged mice developed both ipsilateral and contralateral postinjury mechanical allodynia. In a parallel immunohistochemical analysis of microglial and astrocyte markers, we found that the ipsilateral to the contralateral ratio of nerve injury-induced expression decreased with age. That observation is consistent with our finding of contralateral hypersensitivity after nerve injury in the aged but not the young mice. We conclude that aging has opposite effects on baseline versus postinjury pain and itch processing. PERSPECTIVE Aged male and female mice (22-24 months) are less sensitive to mechanical, thermal (heat), and itch-provoking stimuli than are younger mice (6 months).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Prurito Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Prurito Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos