Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments.

Al-Karmalawy, Ahmed A; Rashed, Mahmoud; Sharaky, Marwa; Abulkhair, Hamada S; Hammouda, Mohamed M; Tawfik, Haytham O; Shaldam, Moataz A

Al-Karmalawy, Ahmed A; Rashed, Mahmoud; Sharaky, Marwa; Abulkhair, Hamada S; Hammouda, Mohamed M; Tawfik, Haytham O; Shaldam, Moataz A.

Afiliación

Al-Karmalawy AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, 12566, Egypt. Electronic address: akarmalawy@acu.edu.eg.
Rashed M; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Sharaky M; Cancer Biology Department, Pharmacology Unit, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.
Abulkhair HS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, 11884, Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University - Egypt, International Coastal Road, New Damietta, 34518, Egypt.
Hammouda MM; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Tawfik HO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt. Electronic address: haytham.omar.mahmoud@pharm.tanta.edu.eg.
Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.

Eur J Med Chem ; 259: 115661, 2023 Nov 05.

Article en En | MEDLINE | ID: mdl-37482023

Asunto(s)

Antineoplásicos; Neoplasias de Cabeza y Cuello; Inhibidores de Topoisomerasa II; Triazinas; Humanos; Antineoplásicos/química; Apoptosis; Línea Celular Tumoral; Proliferación Celular; Doxorrubicina/farmacología; Ensayos de Selección de Medicamentos Antitumorales; Neoplasias de Cabeza y Cuello/tratamiento farmacológico; Simulación del Acoplamiento Molecular; Estructura Molecular; Relación Estructura-Actividad; Triazinas/química; Triazinas/farmacología; Inhibidores de Topoisomerasa II/química; Inhibidores de Topoisomerasa II/farmacología

Palabras clave

Apoptosis; Cytotoxicity; HNSCC; Topoisomerase II; Tricyclic imidazotriazines

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Inhibidores de Topoisomerasa II / Neoplasias de Cabeza y Cuello / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article Pais de publicación: Francia

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