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Prognostic value of myocardial perfusion imaging by cadmium zinc telluride single-photon emission computed tomography in patients with suspected or known coronary artery disease: a systematic review and meta-analysis.
Assante, Roberta; Zampella, Emilia; Cantoni, Valeria; Green, Roberta; D'Antonio, Adriana; Mannarino, Teresa; Gaudieri, Valeria; Nappi, Carmela; Buongiorno, Pietro; Panico, Mariarosaria; Petretta, Mario; Cuocolo, Alberto; Acampa, Wanda.
Afiliación
  • Assante R; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Zampella E; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Cantoni V; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Green R; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • D'Antonio A; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Mannarino T; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Gaudieri V; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Nappi C; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Buongiorno P; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Panico M; Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy.
  • Petretta M; IRCCS SDN, Naples, Italy.
  • Cuocolo A; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
  • Acampa W; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy. acampa@unina.it.
Eur J Nucl Med Mol Imaging ; 50(12): 3647-3658, 2023 10.
Article en En | MEDLINE | ID: mdl-37480369
BACKGROUND: Aim of this study was to define the prognostic value of stress myocardial perfusion imaging by cadmium zinc telluride (CZT) single-photon emission computed tomography (SPECT) for prediction of adverse cardiovascular events in patients with known or suspected coronary artery disease (CAD). METHODS AND RESULTS: Studies published until November 2022 were identified by database search. We included studies using stress myocardial perfusion imaging by CZT-SPECT to evaluate subjects with known or suspected CAD and providing primary data of adverse cardiovascular events. Total of 12 studies were finally included recruiting 36,415 patients. Pooled hazard ratio (HR) for the occurrence of adverse events was 2.17 (95% confidence interval, CI, 1.78-2.65) and heterogeneity was 66.1% (P = 0.001). Five studies reported data on adjusted HR for the occurrence of adverse events. Pooled HR was 1.69 (95% CI, 1.44-1.98) and heterogeneity was 44.9% (P = 0.123). Seven studies reported data on unadjusted HR for the occurrence of adverse events. Pooled HR was 2.72 (95% CI, 2.00-3.70). Nine studies reported data useful to calculate separately the incidence rate of adverse events in patients with abnormal and normal myocardial perfusion. Pooled incidence rate ratio was 2.38 (95% CI, 1.39-4.06) and heterogeneity was 84.6% (P < 0.001). The funnel plot showed no evidence of asymmetry (P = 0.517). At meta-regression analysis, we found an association between HR for adverse events and presence of angina symptoms and family history of CAD. CONCLUSIONS: Stress myocardial perfusion imaging by CZT-SPECT is a valuable noninvasive prognostic indicator for adverse cardiovascular events in patients with known or suspected CAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Imagen de Perfusión Miocárdica Tipo de estudio: Prognostic_studies / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Eur J Nucl Med Mol Imaging Asunto de la revista: MEDICINA NUCLEAR Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Imagen de Perfusión Miocárdica Tipo de estudio: Prognostic_studies / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Eur J Nucl Med Mol Imaging Asunto de la revista: MEDICINA NUCLEAR Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania