Their last will and testament: dying immune cells protect the urinary system with extracellular DNA traps.

Steers, Nicholas J; Barasch, Jonathan

Steers, Nicholas J; Barasch, Jonathan.

Afiliación

Steers NJ; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA. Electronic address: ns3004@cumc.columbia.edu.
Barasch J; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA. Electronic address: jmb4@columbia.edu.

Kidney Int ; 104(2): 236-238, 2023 08.

Article en En | MEDLINE | ID: mdl-37479384

RESUMEN

Like most epithelial organs, the bladder and kidney can be directly accessed by bacteria evolved for invasion. Epithelia and immune cells attempt to stymie this infection with biophysical and chemical mechanisms. Goldspink et al. connected the Na+ gradient in the kidney medulla with an immune defense mounted by dead cells (namely, the explosive death of neutrophils and macrophages), resulting in extracellular DNA traps. The pathway from Na+ concentration to immune death is depicted.

Asunto(s)

Trampas Extracelulares; Inmunidad Innata; Macrófagos; Neutrófilos; Sistema Urinario; Sistema Urinario/inmunología; Neutrófilos/inmunología; Macrófagos/inmunología; Riñón; Sodio; Muerte Celular; Arginina Deiminasa Proteína-Tipo 4; Humanos; Animales; Ratones; Infecciones Urinarias/inmunología; Infecciones Bacterianas/inmunología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Urinario / Trampas Extracelulares / Inmunidad Innata / Macrófagos / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Kidney Int Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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