Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches.

Shi, Chao-Feng; Han, Fei; Jiang, Xiao; Zhang, Zhonghao; Li, Yingqing; Wang, Jiankang; Sun, Shengqi; Liu, Jin-Yi; Cao, Jia

Shi, Chao-Feng; Han, Fei; Jiang, Xiao; Zhang, Zhonghao; Li, Yingqing; Wang, Jiankang; Sun, Shengqi; Liu, Jin-Yi; Cao, Jia.

Afiliación

Shi CF; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Han F; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Jiang X; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhang Z; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Li Y; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Wang J; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Sun S; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Liu JY; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address: jinyiliutmmu@163.com.
Cao J; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address: caojia1962@126.com.

Food Chem Toxicol ; 179: 113941, 2023 Sep.

Article en En | MEDLINE | ID: mdl-37473983

Asunto(s)

Células Intersticiales del Testículo; Proteínas Proto-Oncogénicas c-akt; Masculino; Ratones; Animales; Células Intersticiales del Testículo/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Caspasa 3/metabolismo; Proteína X Asociada a bcl-2/metabolismo; Semen/metabolismo; Testosterona/metabolismo; Apoptosis

Palabras clave

Akt-Mdm2-p53 pathway; Apoptosis; Benzo[b]fluoranthene; Computational toxicology; Leydig cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Células Intersticiales del Testículo Límite: Animals Idioma: En Revista: Food Chem Toxicol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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