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Prevalence and distribution of Plasmodium vivax Duffy Binding Protein gene duplications in Sudan.
Ahmed, Safaa; Pestana, Kareen; Ford, Anthony; Elfaki, Mohammed; Gamil, Eiman; Elamin, Arwa F; Hamad, Samuel Omer; Elfaki, Tarig Mohamed; Abukashawa, Sumaia Mohamed Ahmed; Lo, Eugenia; Abdel Hamid, Muzamil M.
Afiliación
  • Ahmed S; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
  • Pestana K; Department of Zoology, Faculty of Science, University of Khartoum, Khartoum, Sudan.
  • Ford A; Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, United States of America.
  • Elfaki M; Department of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, United States of America.
  • Gamil E; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
  • Elamin AF; Department of Microbiology and Parasitology, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia.
  • Hamad SO; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
  • Elfaki TM; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
  • Abukashawa SMA; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
  • Lo E; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
  • Abdel Hamid MM; National Malaria Control Program, Federal Ministry of Health, Khartoum, Sudan.
PLoS One ; 18(7): e0287668, 2023.
Article en En | MEDLINE | ID: mdl-37471337
Plasmodium vivax Duffy Binding Protein (PvDBP) is essential for interacting with Duffy antigen receptor for chemokines (DARC) on the surface of red blood cells to allow invasion. Earlier whole genome sequence analyses provided evidence for the duplications of PvDBP. It is unclear whether PvDBP duplications play a role in recent increase of P. vivax in Sudan and in Duffy-negative individuals. In this study, the prevalence and type of PvDBP duplications, and its relationship to demographic and clinical features were investigated. A total of 200 malaria-suspected blood samples were collected from health facilities in Khartoum, River Nile, and Al-Obied. Among them, 145 were confirmed to be P. vivax, and 43 (29.7%) had more than one PvDBP copies with up to four copies being detected. Both the Malagasy and Cambodian types of PvDBP duplication were detected. No significant difference was observed between the two types of duplications between Duffy groups. Parasitemia was significantly higher in samples with the Malagasy-type than those without duplications. No significant difference was observed in PvDBP duplication prevalence and copy number among study sites. The functional significance of PvDBP duplications, especially those Malagasy-type that associated with higher parasitemia, merit further investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium vivax / Malaria Vivax Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Sudán Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium vivax / Malaria Vivax Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Sudán Pais de publicación: Estados Unidos