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Reproductive late effects after hematopoietic stem cell transplant in pediatric, adolescent, and young adult cancer survivors.
Appiah, Leslie C; Moravek, Molly; Hoefgen, Holly; Rotz, Seth; Childress, Krista; Samis, Jill; Benoit, Janie; Rodriguez-Wallberg, Kenny; Anazodo, Antoinette.
Afiliación
  • Appiah LC; Department of Obstetrics and Gynecology, Division of Academic Specialists in Obstetrics and Gynecology, University of Colorado School of Medicine, Denver, Colorado, USA.
  • Moravek M; Department of Pediatric and Adolescent Gynecology, Children's Hospital Colorado, Denver, Colorado, USA.
  • Hoefgen H; Department of Reproductive Endocrinology and Infertility, University of Michigan Medicine, Ann Arbor, Michigan, USA.
  • Rotz S; Washington University in St. Louis, St. Louis, Michigan, USA.
  • Childress K; Department of Pediatric Hematology Oncology and Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio, USA.
  • Samis J; Department of Pediatric and Adolescent Gynecology, Primary Children's Medical Center, Salt Lake, Utah, USA.
  • Benoit J; Department of Endocrinology, Lurie Children's Hospital, Chicago, Illinois, USA.
  • Rodriguez-Wallberg K; Université de Montreal, Montreal, Quebec, Canada.
  • Anazodo A; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
Pediatr Blood Cancer ; 70 Suppl 5: e30551, 2023 09.
Article en En | MEDLINE | ID: mdl-37470746
Reproductive late effects after hematopoietic stem cell transplant can have a significant impact on cancer survivors' quality of life. Potential late effects include gonadal insufficiency, genital graft-versus-host disease, uterine injury, psychosexual dysfunction, and an increased risk of breast and cervical cancer in patients treated with total body irradiation. Despite guidelines, screening and treatment are not standardized among at-risk patients. Provider barriers include lack of knowledge of at-risk therapies and evidenced-based guidelines. Patient barriers include a reluctance to report symptoms and lack of awareness of treatment options. System barriers include inefficient implementation of screening tools and poor dissemination of guidelines to providers who serve as the medical home for survivors. This review guides the clinician in identifying and managing reproductive late effects after hematopoietic stem cell transplant to improve outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Trasplante de Células Madre Hematopoyéticas / Supervivientes de Cáncer Tipo de estudio: Guideline Aspecto: Patient_preference Límite: Adolescent / Adult / Child / Female / Humans Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Cuello Uterino / Trasplante de Células Madre Hematopoyéticas / Supervivientes de Cáncer Tipo de estudio: Guideline Aspecto: Patient_preference Límite: Adolescent / Adult / Child / Female / Humans Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos