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Aspartate aminotransferase to platelet ratio index has utility as a biomarker of COVID-19 severity in patients with nonalcoholic fatty liver disease.
Takaya, Hiroaki; Ueyama, Shunichi; Osaki, Yui; Kaji, Kosuke; Kawaratani, Hideto; Saito, Ko; Aizawa, Shigeyuki; Namisaki, Tadashi; Morioka, Chie; Yoshida, Motoyuki; Akahane, Takemi; Yoshiji, Hitoshi.
Afiliación
  • Takaya H; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Ueyama S; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan.
  • Osaki Y; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Kaji K; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Kawaratani H; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan.
  • Saito K; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan.
  • Aizawa S; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Namisaki T; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Morioka C; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan.
  • Yoshida M; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Akahane T; Department of Gastroenterology, Nara Prefecture Seiwa Medical Center, Sango, Nara, Japan.
  • Yoshiji H; Department of Gastroenterology, Nara Medical University, Kashihara, Nara, Japan.
Hepatol Res ; 53(11): 1047-1058, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37469098
AIM: Patients with nonalcoholic fatty liver disease (NAFLD) are reported to have greater coronavirus disease 2019 (COVID-19) severity compared with patients without NAFLD. Previous studies have reported that noninvasive liver fibrosis scores, including the Fibrosis-4 index, NAFLD fibrosis score, and aspartate aminotransferase to platelet ratio index (APRI), have utility in predicting COVID-19 mortality and disease severity in patients without NAFLD. However, the utility of liver fibrosis scores in predicting COVID-19 mortality and disease severity among patients with NAFLD infected with SARS-CoV-2 has yet to be evaluated. METHODS: This retrospective observational study comprised 126 patients with NAFLD and active SARS-CoV-2 infection. Patients were classified into low COVID-19 severity (mild or moderate I disease) and high COVID-19 severity (moderate II or severe disease) groups based on the therapeutic guideline implemented by the Ministry of Health, Labor, and Welfare of Japan. RESULTS: Of the 126 patients, only one had been diagnosed with NAFLD before admission. Age; levels of serum aspartate aminotransferase, γ-glutamyl transpeptidase, lactate dehydrogenase, blood urea nitrogen, and serum C-reactive protein; Fibrosis-4 index; NAFLD fibrosis score; and APRI levels on admission were higher in the high COVID-19 severity group compared with the low COVID-19 severity group. Serum albumin levels, platelet counts, and lymphocyte counts on admission were lower in the high COVID-19 severity group compared with the low COVID-19 severity group. Univariate and multivariate analysis revealed that APRI values were significantly associated with COVID-19 severity and hospitalization duration for COVID-19. CONCLUSIONS: APRI was independently associated with COVID-19 severity and hospitalization duration for COVID-19 in patients with NAFLD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Observational_studies / Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Hepatol Res Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Observational_studies / Prognostic_studies Aspecto: Patient_preference Idioma: En Revista: Hepatol Res Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos