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Keratin-Positive Giant Cell-Rich Tumor of Bone Harboring an HMGA2::NCOR2 Fusion: Two Cases, Including a Patient With Metastatic Disease, and Review of the Literature.
Patton, Ashley; Ilaslan, Hakan; Armstrong, Susan M; Bakhshwin, Ahmed; Cheng, Yu-Wei; Minhas, Farooq; Fritchie, Karen J.
Afiliación
  • Patton A; Department of Pathology & Laboratory Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Ilaslan H; Department of Musculoskeletal Radiology, Cleveland Clinic, Cleveland, OH, USA.
  • Armstrong SM; Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
  • Bakhshwin A; Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
  • Cheng YW; Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
  • Minhas F; Department of Pathology, Ascension Providence Hospital, Southfield, MI, USA.
  • Fritchie KJ; Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
Int J Surg Pathol ; 32(3): 556-564, 2024 May.
Article en En | MEDLINE | ID: mdl-37461232
Giant cell-rich lesions of bone represent a heterogeneous group of entities which classically include giant cell tumor of bone, aneurysmal bone cyst, nonossifying fibroma, and Brown tumor of hyperparathyroidism. A recently described subset of giant cell-rich tumors involving bone and soft tissue has been characterized by recurrent HMGA2::NCOR2 fusions and keratin expression. The overlapping clinical, radiographic, and morphological features of these giant cell-rich lesions provide a unique diagnostic challenge, particularly on biopsy. We present 2 additional cases of keratin-positive giant cell-rich tumor of bone with HMGA2::NCOR2 fusions, including 1 patient who developed metastatic disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Neoplasias Primarias Secundarias / Tumor Óseo de Células Gigantes / Quistes Óseos Aneurismáticos Límite: Humans Idioma: En Revista: Int J Surg Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Neoplasias Primarias Secundarias / Tumor Óseo de Células Gigantes / Quistes Óseos Aneurismáticos Límite: Humans Idioma: En Revista: Int J Surg Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos