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Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption.
Wei, Jinfu; Lin, Zihong; Dai, Zeyu; Zhou, Zibin; Bi, Yonghao; Zheng, Ruiwu; Hu, Xianghua; Xu, Zhaoxin; Yuan, Guixin; Wang, Weidong.
Afiliación
  • Wei J; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Lin Z; Department of Shantou Central Hospital, Shantou, 515000, Guangdong, China.
  • Dai Z; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Zhou Z; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Bi Y; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Zheng R; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Hu X; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Xu Z; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China.
  • Yuan G; Department of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, 515000, Guangdong, China. yuixinguan@foxmail.com.
  • Wang W; Department of Bone and Soft Tissue Oncology Surgery, Cancer Hospital of Shantou University Medical College, Shantou, 515000, Guangdong, China. 07wdwang@stu.edu.cn.
In Vitro Cell Dev Biol Anim ; 59(6): 420-430, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37460875
Brevilin A (BA) is the primary component of Centipeda minima, which is widely used in Chinese traditional medicine. The anti-inflammatory and anti-tumor properties of BA have been established; however, its function in bone metabolism is not well understood. This study revealed that concentrations of BA below 1.0 µM did not inhibit the proliferation of bone marrow macrophages but did impede the differentiation and bone resorption activity of osteoclasts. Furthermore, BA suppressed the expression of osteoclast-specific genes Mmp9, Acp5, Dc-stamp, Ctsk, and Atp6v0d2. In addition, mTOR, ERK, and NFATc1 activation in bone marrow macrophages were suppressed by BA. As a whole, BA blocks the mTOR and ERK signaling pathways, which is responsible for the development and activity of osteoclasts, and the resorption of bone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoclastos / Resorción Ósea Límite: Animals Idioma: En Revista: In Vitro Cell Dev Biol Anim Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoclastos / Resorción Ósea Límite: Animals Idioma: En Revista: In Vitro Cell Dev Biol Anim Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania