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Telomere length and verbal learning in bipolar disorders.
Mlakar, Vid; Birkenæs, Viktoria; Elvsaashagen, Torbjørn; Ormerod, Monica B E G; Quintana, Daniel S; Ueland, Torill; Melle, Ingrid; Lagerberg, Trine V; Djurovic, Srdjan; Martin-Ruiz, Carmen; Steen, Nils Eiel; Andreassen, Ole A; Aas, Monica.
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  • Mlakar V; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
  • Birkenæs V; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Elvsaashagen T; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Ormerod MBEG; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Quintana DS; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway; NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway.
  • Ueland T; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.
  • Melle I; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Lagerberg TV; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Djurovic S; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
  • Martin-Ruiz C; BioScreening Core Facility-CAV, Ageing Research Laboratories, Newcastle University, Campus for Ageing and Vitality, UK.
  • Steen NE; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Andreassen OA; NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Norway.
  • Aas M; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Dept. of Behavioural Sciences, OsloMet - Osl
J Affect Disord ; 339: 555-560, 2023 10 15.
Article en En | MEDLINE | ID: mdl-37459977
INTRODUCTION: Recent studies indicate accelerated ageing processes, shorter telomere length and poorer cognitive functioning in patients with bipolar disorder. The neurobiology underlying cognitive function in bipolar disorder is yet to be established. We anticipated that accelerated ageing as indicated by shortened telomere length, would be associated with reduced cognitive performance in bipolar disorder, particularly for ageing sensitive functions such as memory and learning. METHODS: The study consisted of 647 participants (bipolar disorder [n = 246] and healthy controls [n = 401]). All participants underwent a standardized neuropsychological test battery, including working memory, executive functioning, processing speed, verbal learning, and verbal memory. Leucocyte telomere length was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio). The T/S ratio was used as an estimate of the mean telomere length of each participant. All analyses were adjusted for medication, Daily Defined Dose (DDD), chronological age, sex, and ethnicity. RESULTS: Patients had shorter telomere lengths than healthy controls (Cohen's d = 0.11, p = 0.01). Within patients', a positive association was observed for verbal learning and telomere length (ß = 0.14, p = 0.025), along with a trend for verbal memory and telomere length (ß = 0.11, p = 0.07). No other associations were observed for telomere length and cognitive functioning in the patient or the control group (p > 0.1). CONCLUSION: Our study may suggest poorer brain health in bipolar disorder as indexed by shorter telomere length and reduced learning correlates. However, the role of telomere length on cognitive functioning in bipolar disorder seems limited.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar Límite: Humans Idioma: En Revista: J Affect Disord Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar Límite: Humans Idioma: En Revista: J Affect Disord Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos