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Case Report: SMARCA4 (BRG1)-deficient undifferentiated carcinoma of gallbladder with genetic analysis.
Meng, Xiangpeng; Ma, Jia; Meng, Nan; Yun, Tianyu; Niu, Beifang.
Afiliación
  • Meng X; Pancreatic Endocrinology Ward, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
  • Ma J; Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
  • Meng N; Beijing ChosenMed Clinical Laboratory Co. Ltd., Beijing, China.
  • Yun T; Beijing ChosenMed Clinical Laboratory Co. Ltd., Beijing, China.
  • Niu B; Beijing ChosenMed Clinical Laboratory Co. Ltd., Beijing, China.
Front Oncol ; 13: 1086266, 2023.
Article en En | MEDLINE | ID: mdl-37456262
SMARCA4 (BRG1)-deficient undifferentiated carcinoma is a rare and highly aggressive malignancy. It has been reported to occur in a multiple range of organs. However, to the best of our knowledge, SMARCA4 (BRG1)-deficient undifferentiated carcinoma of gallbladder has not yet been reported. Here, we describe a case of SMARCA4 (BRG1)-deficient undifferentiated carcinoma of gallbladder. Through comprehensive genetic analysis, we hypothesized that in addition to SMARCA4 (BRG1) deficiency, other genetic changes might also be involved in the tumorigenesis of undifferentiated gallbladder cancer in this patient, particularly somatic mutations in the CTNNB1, KRAS, PIK3CA, TP53, CREBBP, and FANCI genes. To the best of our knowledge, this is the first report of SMARCA4 (BRG1)-deficient undifferentiated carcinoma of gallbladder with genetic analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza