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Lnc-HULC, miR-122, and sirtulin-1 as potential diagnostic biomarkers for psoriasis and their association with the development of metabolic syndrome during the disease course.
Erfan, Randa; Shaker, Olfat G; Khalil, Mahmoud A F; AlOrbani, Aya M; Abu-El-Azayem, Abeer K; Samy, Amira; Zaki, Othman M; Abdelhamid, Haitham; Fares, Reham; Mohammed, Asmaa.
Afiliación
  • Erfan R; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, 12613, Egypt.
  • Shaker OG; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, 12613, Egypt.
  • Khalil MAF; Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt.
  • AlOrbani AM; Department of Dermatology, Faculty of Medicine, Cairo University, 12613, Egypt.
  • Abu-El-Azayem AK; Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, 12613, Cairo, Egypt.
  • Samy A; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, 12613, Cairo, Egypt.
  • Zaki OM; Department of Clinical Pathology, Faculty of Medicine, Damietta University, Damietta, Egypt.
  • Abdelhamid H; Plastic Surgery Center, Haar Restore Klinik, Cairo, 12613, Egypt.
  • Fares R; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt.
  • Mohammed A; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, 63514, Egypt.
Noncoding RNA Res ; 8(3): 340-349, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37455763
Psoriasis is a persistent inflammatory skin disorder driven by T cells. The disease is characterized by aberrant keratinocytes (KCs) differentiation, epidermal proliferation, and excessive hyperplasia of veins and arteries. The purpose of the study was to identify the levels of circulating lnc-HULC, miR-122, and Sirtuin 1 (SIRT-1) in psoriatic patients, evaluate their possible roles as diagnostic biomarkers, and link their levels with the development of metabolic syndrome during psoriasis progression. This study included 176 participants. The subjects were divided into four groups, with 44 participants in each group. All patients have undergone a complete history taking and clinical examination. Laboratory investigations included Low-density lipoprotein (LDL), High-density lipoprotein (HDL), Triglycerides (TG), Fasting blood sugar (FBS), and cholesterol plasma levels. Serum levels of miR-122 and lnc-HULC were examined by qRT-PCR. Serum levels of SIRT-1 were examined by ELISA. The serum concentrations of lnc-HULC and miR-122 were significantly higher in psoriatic participants compared to controls. Psoriatic patients' serum concentrations of SIRT-1 were much lower than those of healthy individuals. There was a negative association between SIRT-1 concentration and BMI, disease duration, PASI score, LDL, and cholesterol levels. The blood levels of lnc-HULC, miR-122, and SIRT-1 in psoriasis patients provide a promising role as diagnostic biomarkers in patients with and without metabolic syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Noncoding RNA Res Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Noncoding RNA Res Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Países Bajos