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Lanostane triterpenoids with anti-proliferative and anti-inflammatory activities from medicinal mushroom Ganoderma lingzhi.
Zhao, Zhen-Zhu; Ji, Bao-Yu; Wang, Zhen-Zhen; Si, Ying-Ying; Sun, Yan-Jun; Chen, Hui; Feng, Wei-Sheng; Zheng, Xiao-Ke; Liu, Ji-Kai.
Afiliación
  • Zhao ZZ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Ji BY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Wang ZZ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Si YY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Sun YJ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Chen H; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Feng WS; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Zheng XK; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.
  • Liu JK; School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China. Electronic address: liujikai@mail.scuec.edu.cn.
Phytochemistry ; 213: 113791, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37454886
Eight previously undescribed lanostane triterpenoids and nine known ones were identified from the fruiting bodies of Ganoderma lingzhi S.H. Wu, Y. Cao & Y.C. Dai. Their structures were determined based on spectroscopic data and quantum chemical calculations. Structurally, ganoderane GL-1, featuring a hydrogenated tetramethyls-phenanthraquinone, represents the first example in lanostane nor-triterpenoid group. Biologically, ganoderanes GL-2 and GL-3, distinguished by the presence of a rare "1,11-epoxy" moiety, exhibited significant inhibition against nitric oxide production induced by lipopolysaccharide in RAW264.7 macrophage cells, while ganoderanes GL-4 and GL-8 exhibited bifunctional activities of anti-proliferation and anti-inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Ganoderma / Agaricales Idioma: En Revista: Phytochemistry Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Ganoderma / Agaricales Idioma: En Revista: Phytochemistry Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido