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Phase separation on microtubules: from droplet formation to cellular function?
Volkov, Vladimir A; Akhmanova, Anna.
Afiliación
  • Volkov VA; School of Biological and Behavioural Sciences, Queen Mary University of London, London, E1 4NS, UK. Electronic address: v.volkov@qmul.ac.uk.
  • Akhmanova A; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands. Electronic address: a.akhmanova@uu.nl.
Trends Cell Biol ; 34(1): 18-30, 2024 01.
Article en En | MEDLINE | ID: mdl-37453878
Microtubules are cytoskeletal polymers that play important roles in numerous cellular processes, ranging from the control of cell shape and polarity to cell division and intracellular transport. Many of these roles rely on proteins that bind to microtubule ends and shafts, carry intrinsically disordered regions, and form complex multivalent interaction networks. A flurry of recent studies demonstrated that these properties allow diverse microtubule-binding proteins to undergo liquid-liquid phase separation (LLPS) in vitro. It is proposed that LLPS could potentially affect multiple microtubule-related processes, such as microtubule nucleation, control of microtubule dynamics and organization, and microtubule-based transport. Here, we discuss the evidence in favor and against the occurrence of LLPS and its functional significance for microtubule-based processes in cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Separación de Fases / Microtúbulos Límite: Humans Idioma: En Revista: Trends Cell Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Separación de Fases / Microtúbulos Límite: Humans Idioma: En Revista: Trends Cell Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido