Phase separation on microtubules: from droplet formation to cellular function?
Trends Cell Biol
; 34(1): 18-30, 2024 01.
Article
en En
| MEDLINE
| ID: mdl-37453878
Microtubules are cytoskeletal polymers that play important roles in numerous cellular processes, ranging from the control of cell shape and polarity to cell division and intracellular transport. Many of these roles rely on proteins that bind to microtubule ends and shafts, carry intrinsically disordered regions, and form complex multivalent interaction networks. A flurry of recent studies demonstrated that these properties allow diverse microtubule-binding proteins to undergo liquid-liquid phase separation (LLPS) in vitro. It is proposed that LLPS could potentially affect multiple microtubule-related processes, such as microtubule nucleation, control of microtubule dynamics and organization, and microtubule-based transport. Here, we discuss the evidence in favor and against the occurrence of LLPS and its functional significance for microtubule-based processes in cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Separación de Fases
/
Microtúbulos
Límite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido