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Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5.
Giri, Anil K; Aavikko, Mervi; Wartiovaara, Linnea; Lemmetyinen, Toni; Karjalainen, Juha; Mehtonen, Juha; Palin, Kimmo; Välimäki, Niko; Tamlander, Max; Saikkonen, Riikka; Karhu, Auli; Morgunova, Ekaterina; Sun, Benjamin; Runz, Heiko; Palta, Priit; Luo, Shuang; Joensuu, Heikki; Mäkelä, Tomi P; Kostiainen, Iiro; Schalin-Jäntti, Camilla; Palotie, Aarno; Aaltonen, Lauri A; Ollila, Saara; Daly, Mark J.
Afiliación
  • Giri AK; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Foundation for the Finnish Cancer Institute, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki Institute of Life Science, University of Helsinki, Helsin
  • Aavikko M; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Wartiovaara L; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Lemmetyinen T; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Karjalainen J; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and Massach
  • Mehtonen J; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Palin K; iCAN Digital Precision Cancer Medicine Flagship, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Välimäki N; Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Tamlander M; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Saikkonen R; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Karhu A; Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Morgunova E; Karolinska Institute, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden.
  • Sun B; Translational Biology, Research and Development, Biogen Inc, Cambridge, Massachusetts.
  • Runz H; Translational Biology, Research and Development, Biogen Inc, Cambridge, Massachusetts.
  • Palta P; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Luo S; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Joensuu H; Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  • Mäkelä TP; iCAN Digital Precision Cancer Medicine Flagship, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Kostiainen I; Endocrinology, Abdominal Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
  • Schalin-Jäntti C; Endocrinology, Abdominal Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
  • FinnGen; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
  • Palotie A; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachuse
  • Aaltonen LA; Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Ollila S; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Daly MJ; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and Massach
Gastroenterology ; 165(4): 861-873, 2023 10.
Article en En | MEDLINE | ID: mdl-37453564
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tumores Neuroendocrinos / Neoplasias Intestinales Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Gastroenterology Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tumores Neuroendocrinos / Neoplasias Intestinales Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Gastroenterology Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos