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Pharmacological assessment of the antineoplastic and immunomodulatory properties of a new spiroindolone derivative (7',8'-Dimethoxy-1',3'-dimethyl-1,2,3',4'-tetrahydrospiro[indole-3,5'-pyrazolo[3,4-c]isoquinolin]-2-one) in chronic myeloid leukemia.
de Castro Alves, Carlos Eduardo; Bogza, Serge L; Bohdan, Nathalie; Rozhenko, Alexander B; de Freitas Gomes, Alice; de Oliveira, Regiane Costa; de Azevedo, Renata Galvão; Maciel, Larissa Raquel Silva; Dhyani, Anamika; Grafov, Andriy; Pontes, Gemilson Soares.
Afiliación
  • de Castro Alves CE; Post-Graduate Program in Basic and Applied Immunology, Institute of Biological Science, Federal University of Amazonas, Manaus, 69077-000, AM, Brazil.
  • Bogza SL; Laboratory of Virology and Immunology, National Institute of Amazonian Research (INPA), Manaus, 69067- 375, AM, Brazil.
  • Bohdan N; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Academician Kukhar str. 5, Kyiv, 02094, Ukraine.
  • Rozhenko AB; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Academician Kukhar str. 5, Kyiv, 02094, Ukraine.
  • de Freitas Gomes A; Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Academician Kukhar str. 5, Kyiv, 02094, Ukraine.
  • de Oliveira RC; National Technical University of Ukraine 'Igor Sikorsky Kyiv Polytechnic Institute', Beresteiskyi prosp. 37, Kyiv, 03056, Ukraine.
  • de Azevedo RG; Post-Graduate Program in Hematology, Foundation of Hematology and Hemotherapy of Amazonas, The State University of Amazon, Manaus, 69050-010, AM, Brazil.
  • Maciel LRS; Post-Graduate Program in Basic and Applied Immunology, Institute of Biological Science, Federal University of Amazonas, Manaus, 69077-000, AM, Brazil.
  • Dhyani A; Post-Graduate Program in Basic and Applied Immunology, Institute of Biological Science, Federal University of Amazonas, Manaus, 69077-000, AM, Brazil.
  • Grafov A; Laboratory of Virology and Immunology, National Institute of Amazonian Research (INPA), Manaus, 69067- 375, AM, Brazil.
  • Pontes GS; Post-Graduate Program in Hematology, Foundation of Hematology and Hemotherapy of Amazonas, The State University of Amazon, Manaus, 69050-010, AM, Brazil.
Invest New Drugs ; 41(5): 629-637, 2023 10.
Article en En | MEDLINE | ID: mdl-37452982
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Invest New Drugs Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Invest New Drugs Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos