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Prevalence and outcomes of type 2 myocardial infarction in patients with cancer: A retrospective analysis from the National Inpatient Sample dataset.
Castaldi, Gianluca; Bharadwaj, Aditya S; Bagur, Rodrigo; Van Spall, Harriette G C; Kobo, Ofer; Mamas, Mamas A.
Afiliación
  • Castaldi G; Ziekenhuis Netwerk Antwerpen Middelheim, Antwerp, Belgium.
  • Bharadwaj AS; Division of Cardiology, Loma Linda University Health, California, USA.
  • Bagur R; London Health Sciences Centre, Division of Cardiology, Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
  • Van Spall HGC; Department of Medicine and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada; Research Institute of St. Joseph's, Hamilton, Canada; Population Health Research Institute, Hamilton, Canada.
  • Kobo O; Department of Cardiology, Hillel Yaffe Medical Center, Hadera, Israel.
  • Mamas MA; Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Stoke-on-Trent, UK. Electronic address: mamasmamas1@yahoo.co.uk.
Int J Cardiol ; 389: 131154, 2023 10 15.
Article en En | MEDLINE | ID: mdl-37442352
BACKGROUND: This study aimed to investigate the prevalence, clinical characteristics and outcomes of type 2 myocardial infarction (T2AMI) in patients with versus without cancer. METHODS: All hospitalizations with a primary discharge diagnosis of T2AMI were stratified according to cancer status (secondary diagnosis of any-cancer vs cancer-free) using data from the US National Inpatient Sample (2016-2019). The primary outcome was in-hospital all-cause mortality while secondary outcomes were in-hospital major adverse cardiovascular and cerebrovascular events (MACCE). RESULTS: Among 61,305 included hospitalizations with primary diagnosis of T2AMI, 3745 (6.1%) were associated with a diagnosis of cancer. Patients with T2AMI and cancer presented more frequently with acute respiratory failure (23.2% vs 18.1%), acute pulmonary embolism (3.7% v 1.3%), major bleeding (6.8% vs 4.1%) and renal failure (51.0% vs 46.8%), compared to patients without. On adjusted analysis, diagnosis of cancer was associated with lower odds of invasive coronary angiography (aOR 0.75, 95% CI 0.60 to 0.93, p = 0.009) but greater odds of mortality (aOR 1.95, 95% C.I. 1.26-2.99 p = 0.002). Among the different types of cancer, adjusted risk of all-cause mortality was higher in patients with colorectal (aOR 4.17 95% CI 1.68-10.32, p = 0.002), lung (aOR 3.63, 95% CI 1.83-7.18, p < 0.001) and haematologic (aOR 2.48, 95% CI 1.22-5.05, p = 0.001) cancer. CONCLUSIONS: Patients with cancer presenting with T2AMI have lower odds of management with invasive diagnostic coronary angiography and have higher rates of in-hospital all-cause death. Further studies are warranted to improve overall care and outcomes of cancer patients and cardiovascular diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto de la Pared Anterior del Miocardio / Infarto del Miocardio / Neoplasias Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Cardiol Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infarto de la Pared Anterior del Miocardio / Infarto del Miocardio / Neoplasias Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Cardiol Año: 2023 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos