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LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.
Anstee, Joanne E; Feehan, Karen T; Opzoomer, James W; Dean, Isaac; Muller, Henrike P; Bahri, Meriem; Cheung, Tik Shing; Liakath-Ali, Kifayathullah; Liu, Ziyan; Choy, Desmond; Caron, Jonathan; Sosnowska, Dominika; Beatson, Richard; Muliaditan, Tamara; An, Zhengwen; Gillett, Cheryl E; Lan, Guocheng; Zou, Xiangang; Watt, Fiona M; Ng, Tony; Burchell, Joy M; Kordasti, Shahram; Withers, David R; Lawrence, Toby; Arnold, James N.
Afiliación
  • Anstee JE; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Feehan KT; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Opzoomer JW; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Dean I; Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
  • Muller HP; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Bahri M; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Cheung TS; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Liakath-Ali K; Centre for Stem Cells and Regenerative Medicine, King's College London, London SE1 9RT, UK.
  • Liu Z; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Choy D; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Caron J; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Sosnowska D; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Beatson R; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Muliaditan T; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • An Z; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Gillett CE; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Lan G; Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK.
  • Zou X; Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK.
  • Watt FM; Centre for Stem Cells and Regenerative Medicine, King's College London, London SE1 9RT, UK.
  • Ng T; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK; UCL Cancer Institute, University College London, London WC1E 6DD, UK.
  • Burchell JM; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK.
  • Kordasti S; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK; Haematology Department, Guy's Hospital, London SE1 9RT, UK.
  • Withers DR; Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
  • Lawrence T; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London SE1 1UL, UK; Aix Marseille University, CNRS, INSERM, CIML, Marseille, France; Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xi
  • Arnold JN; School of Cancer and Pharmaceutical Sciences, King's College London, London SE1 1UL, UK. Electronic address: james.arnold@kcl.ac.uk.
Dev Cell ; 58(17): 1548-1561.e10, 2023 09 11.
Article en En | MEDLINE | ID: mdl-37442140
Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete. Here, we describe a population of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)-expressing TAMs, which form coordinated multi-cellular "nest" structures that are heterogeneously distributed proximal to vasculature in tumors of a spontaneous murine model of breast cancer. We demonstrate that LYVE-1+ TAMs develop in response to IL-6, which induces their expression of the immune-suppressive enzyme heme oxygenase-1 and promotes a CCR5-dependent signaling axis, which guides their nest formation. Blocking the development of LYVE-1+ TAMs or their nest structures, using gene-targeted mice, results in an increase in CD8+ T cell recruitment to the tumor and enhanced response to chemotherapy. This study highlights an unappreciated collaboration of a TAM subset to form a coordinated niche linked to immune exclusion and resistance to anti-cancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos