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Determination of immunological biomarkers in sarcoidosis and their relation to disease activity.
Ibrahim, Radwa S; Hassan, Asmaa S; Moazen, Eman M; Mohamed, Eman K.
Afiliación
  • Ibrahim RS; Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Hassan AS; Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Moazen EM; Department of Chest, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Mohamed EK; Department of Blood Bank, Al Haram Hospital, Specialized Medical Centers, Giza, Egypt.
Egypt J Immunol ; 30(3): 92-101, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37440331
Sarcoidosis is a multisystem granulomatous disease of unknown origin. Ninety percent of patients with sarcoidosis have lung involvement. The onset can be acute or non-acute and the severity of sarcoidosis ranges widely from asymptomatic patients with accidental radiographic findings to patients with severe organ involvement. This case control analytic prospective study was conducted at the Chest Clinic, Al Zahraa hospital, to assess the diagnostic value of serum soluble interleukin 2 receptor (sIL-2R), cluster of differentiation 4 (CD4)/CD8 ratio and CD103 in sarcoidosis. We investigated the value of serum sIL-2R using ELISA and blood CD103, blood CD4/CD8 ratio using flow cytometry for 30 cases of sarcoidosis in different stages and 30 control persons to detect their use as a marker for diagnosis. We found a significant increase in sIL-2R in the sarcoidosis group as compared to the control group (p˂0.0001), while there was a significant decrease in CD103/CD4 in sarcoidosis group as compared to the control group (p < 0.001). In conclusion, sIL-2R and CD103 can be used as diagnostic markers for sarcoidosis.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoidosis Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoidosis Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Humans Idioma: En Revista: Egypt J Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Egipto