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Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort.
Wlodarczak, Adrian; Rola, Piotr; Barycki, Mateusz; Furtan, Lukasz; Lanocha, Magdalena; Wlodarczak, Szymon; Szudrowicz, Marek; Kulczycki, Jan Jakub; Jaroszewska-Pozorska, Joanna; Kedzierska, Michalina; Giniewicz, Katarzyna; Doroszko, Adrian; Lesiak, Maciej.
Afiliación
  • Wlodarczak A; Faculty of Health Sciences and Physical Culture, Witelon Collegium State University, Legnica, Poland.
  • Rola P; Department of Cardiology, The Copper Health Centre (MCZ), Lubin, Poland.
  • Barycki M; Faculty of Health Sciences and Physical Culture, Witelon Collegium State University, Legnica, Poland.
  • Furtan L; Department of Cardiology, Provincial Specialized Hospital in Legnica, Legnica, Poland.
  • Lanocha M; Department of Cardiology, Provincial Specialized Hospital in Legnica, Legnica, Poland.
  • Wlodarczak S; Department of Cardiology, Provincial Specialized Hospital in Legnica, Legnica, Poland.
  • Szudrowicz M; Adalbert's Hospital, Poznan, Poland.
  • Kulczycki JJ; Department of Cardiology, The Copper Health Centre (MCZ), Lubin, Poland.
  • Jaroszewska-Pozorska J; Department of Cardiology, The Copper Health Centre (MCZ), Lubin, Poland.
  • Kedzierska M; Department of Cardiology, The Copper Health Centre (MCZ), Lubin, Poland.
  • Giniewicz K; Department of Cardiology, The Copper Health Centre (MCZ), Lubin, Poland.
  • Doroszko A; Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
  • Lesiak M; Professional Medical Statistician, Wroclaw, Poland.
Diab Vasc Dis Res ; 20(4): 14791641231188705, 2023.
Article en En | MEDLINE | ID: mdl-37439002
BACKGROUND: Diabetes type 2 is one of the strongest risk factors affecting coronary artery disease (CAD) and is also a marker of poor short and long-term prognosis in subjects with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) with subsequent drug-eluting stent (DES) implantation. Chronic local vascular inflammation along with endothelial dysfunction is postulated to be the pathophysiological background of unfavorable results. The second generation of metallic magnesium BRS -Magmaris (Biotronik, Berlin, Germany) had been introduced to clinical practice to overcome these limitations. METHODS: We evaluated 2-years clinical outcomes after Magmaris BRS implantation in NSTE-ACS diabetic (n-72) and non-diabetic (n-121) cohorts. RESULTS: No significant differences between diabetic and non-diabetes cohorts were noticed in terms of Primary Outcome (cardiac death, myocardial infarction, stent thrombosis) (8.1% vs 3.3% p = 0.182) and Principal secondary outcome - TLF- target lesion failure (9.5% vs 3.3% p = 0.106) at 2-years follow-up. CONCLUSIONS: 2-years outcome suggests good safety and efficacy of the magnesium BRS (Magmaris) in NSTE- ACS and concomitant DM. Nevertheless, there is a strong need for large multicenter, randomized, prospective studies for a full assessment of this novel device in diabetic patients with ACS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Síndrome Coronario Agudo / Stents Liberadores de Fármacos / Intervención Coronaria Percutánea Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Diab Vasc Dis Res Asunto de la revista: ANGIOLOGIA / ENDOCRINOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Síndrome Coronario Agudo / Stents Liberadores de Fármacos / Intervención Coronaria Percutánea Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Diab Vasc Dis Res Asunto de la revista: ANGIOLOGIA / ENDOCRINOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido