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Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population.
Shigdel, Rajesh; Johannessen, Ane; Lin, Huang; Peddada, Shyamal; Gómez Real, Francisco; Ringel-Kulka, Tamar; Svanes, Cecilie; Bertelsen, Randi Jacobsen.
Afiliación
  • Shigdel R; Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020, Bergen, Norway. shigdelrajesh@gmail.com.
  • Johannessen A; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • Lin H; Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Bethesda, MD, 20892, USA.
  • Peddada S; Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Bethesda, MD, 20892, USA.
  • Gómez Real F; Department of Clinical Science, University of Bergen, P.O. Box 7804, N-5020, Bergen, Norway.
  • Ringel-Kulka T; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
  • Svanes C; UNC Gillings School of Global Public Health, Department of Maternal and Child Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Bertelsen RJ; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.
Respir Res ; 24(1): 183, 2023 Jul 12.
Article en En | MEDLINE | ID: mdl-37438766
BACKGROUND: The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about the relationship between oral bacteria and respiratory outcomes in the general population. We aimed to describe the associations between oral bacteria, lung function, and lung inflammation in a community-based population. METHODS: Oral (gingival) samples were collected concurrently with spirometry tests in 477 adults (47% males, median age 28 years) from the RHINESSA study in Bergen, Norway. Bacterial DNA from the 16S rRNA gene from gingival fluid were sequenced by Illumina®MiSeq. Lung function was measured using spirometry and measurement of fractional exhaled nitric oxide (FeNO) were performed to examine airway inflammation. Differential abundance analysis was performed using ANCOM-BC, adjusting for weight, education, and smoking. RESULTS: The abundance of the genera Clostridiales, Achromobacter, Moraxella, Flavitalea and Helicobacter were significantly different among those with low FEV1 (< lower limit of normal (LLN)) as compared to normal FEV1 i.e. ≥ LLN. Twenty-three genera differed in abundance between among those with low FVC < LLN as compared to normal FEV1 ≥ LLN. The abundance of 27 genera from phyla Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria and Sacchribacteria differed significantly between elevated FeNO levels (≥ 50 ppb) compared to FeNO ≤ 25 ppb. CONCLUSION: Oral bacterial composition was significantly different for those with low FEV or FVC as compared to those with normal lung function equal to or higher than LLN. Differential bacterial composition was also observed for elevated FeNO levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Respir Res Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Respir Res Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido