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Genetic and pathogenic characterization of an NADC-34-like isolate of porcine reproductive and respiratory syndrome virus.
Zhao, Yongxin; Wang, Ruiqing; Li, Wei; Yu, Chenfei; Zhang, Riteng; Hu, Ruochen; Guo, Ruhai; Yang, Zengqi; Zhou, Yefei; Wang, Xinglong.
Afiliación
  • Zhao Y; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Wang R; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Li W; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Yu C; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Zhang R; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Hu R; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Guo R; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Yang Z; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China.
  • Zhou Y; Department of Life Science, Nanjing Xiaozhuang University, 211171, Jiangsu, Nanjing, China. yfzhou@njxzc.edu.cn.
  • Wang X; College of Veterinary Medicine, Northwest A&F University, 712100, Yangling, Shaanxi, China. wxlong@nwsuaf.edu.cn.
Arch Virol ; 168(8): 205, 2023 Jul 12.
Article en En | MEDLINE | ID: mdl-37436532
In this study, an NADC34-like strain of porcine reproductive and respiratory syndrome virus (PRRSV), YC-2020, was isolated from a pig farm in Yuncheng, Shanxi Province, China. Phylogenetic and molecular evolutionary analysis showed that the genome sequence of YC-2020 was very similar to those of NADC34-like PRRSV strains in the ORF2-7 region. However, it was more closely related to NADC30-like PRRSV and highly pathogenic (HP) PRRSV in the NSP2 and NSP3-9 coding regions, respectively, suggesting that recombination had occurred between viruses belonging to lineages 1 and 8. Piglets infected with YC-2020 exhibited mild clinical signs, but they had severe histopathological lesions in their lungs. These findings reveal novel genetic and pathogenic features of this isolate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus del Síndrome Respiratorio y Reproductivo Porcino / Síndrome Respiratorio y de la Reproducción Porcina Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Arch Virol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus del Síndrome Respiratorio y Reproductivo Porcino / Síndrome Respiratorio y de la Reproducción Porcina Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Arch Virol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Austria