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Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder - a longitudinal sibling control study.
Gustavson, Kristin; Ystrom, Eivind; Ask, Helga; Ask Torvik, Fartein; Hornig, Mady; Susser, Ezra; Lipkin, W Ian; Lupattelli, Angela; Stoltenberg, Camilla; Magnus, Per; Mjaaland, Siri; Askeland, Ragna Bugge; Walle, Kjersti Mæhlum; Bresnahan, Michaeline; Nordeng, Hedvig; Reichborn-Kjennerud, Ted.
Afiliación
  • Gustavson K; Norwegian Institute of Public Health Oslo Norway.
  • Ystrom E; Promenta Research Center University of Oslo Oslo Norway.
  • Ask H; Norwegian Institute of Public Health Oslo Norway.
  • Ask Torvik F; Promenta Research Center University of Oslo Oslo Norway.
  • Hornig M; Norwegian Institute of Public Health Oslo Norway.
  • Susser E; Department of Psychology University of Oslo Oslo Norway.
  • Lipkin WI; Center for Fertility and Health Norwegian Institute of Public Health Oslo Norway.
  • Lupattelli A; Mailman School of Public Health Columbia University New York NY USA.
  • Stoltenberg C; Mailman School of Public Health Columbia University New York NY USA.
  • Magnus P; New York State Psychiatric Institute New York NY USA.
  • Mjaaland S; Department of Epidemiology Columbia University Mailman School of Public Health New York NY USA.
  • Askeland RB; Center for Infection and Immunity Columbia University Mailman School of Public Health New York NY USA.
  • Walle KM; Departments of Neurology and Pathology Mailman School of Public Health New York NY USA.
  • Bresnahan M; College of Physicians and Surgeons Columbia University New York NY USA.
  • Nordeng H; Pharmacoepidemiology and Drug Safety Research Group Department of Pharmacy, and PharmaTox Strategic Research Initiative Faculty of Mathematics and Natural Sciences University of Oslo Oslo Norway.
  • Reichborn-Kjennerud T; Norwegian Institute of Public Health Oslo Norway.
JCPP Adv ; 1(2): e12020, 2021 Jul.
Article en En | MEDLINE | ID: mdl-37431475
Background: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding factors. The aim of the current study was to examine unmeasured familial confounding factors of this association. Methods: We used data from 26,613 children from 12,902 families participating in the prospective Norwegian Mother, Father, and Child Cohort Study (MoBa). The MoBa was linked to the Norwegian Medical Birth Register and the Norwegian Patient Registry. Siblings discordant for prenatal acetaminophen exposure were compared regarding risk of having an ADHD diagnosis. Results: Children exposed to acetaminophen up to 28 days during pregnancy did not have increased risk of receiving an ADHD diagnosis compared to unexposed children. The adjusted Hazard ratio (aHR) was 0.87 (95% C.I. = 0.70-1.08) for exposure 1 to 7 days, and 1.13 (95% C.I. = 0.82-1.49) for 8-28 days. Long-term exposure (29 days or more) was associated with a two-fold increase in risk of ADHD diagnosis (aHR = 2.02, 95% C.I = 1.17-3.25). In the sibling control model, the association between long-term acetaminophen use and ADHD in the child was aHR = 2.77 (95% C.I. = 1.48-5.05) at the between-family level, and aHR = 1.06 (95% C.I. = 0.51-2.05) at the within-family level. Conclusions: Both the exposed and the unexposed children of mothers with long-term use of acetaminophen in one of the pregnancies had increased risk of receiving an ADHD diagnosis. This indicates that the observed association between long-term acetaminophen use during pregnancy and ADHD in the child may at least partly be confounded by unobserved family factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: JCPP Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: JCPP Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos