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Emergence of novel genomic regulatory regions associated with light-organ development in the bobtail squid.
Rouressol, Lisa; Briseno, John; Vijayan, Nidhi; Chen, Grischa Y; Ritschard, Elena A; Sanchez, Gustavo; Nyholm, Spencer V; McFall-Ngai, Margaret J; Simakov, Oleg.
Afiliación
  • Rouressol L; Department for Neurosciences and Developmental Biology, University of Vienna, Vienna 1030, Austria.
  • Briseno J; Department of Biosphere Sciences and Engineering, Carnegie Institution for Science, Pasadena, CA 91125, USA.
  • Vijayan N; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.
  • Chen GY; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.
  • Ritschard EA; Department of Biosphere Sciences and Engineering, Carnegie Institution for Science, Pasadena, CA 91125, USA.
  • Sanchez G; Department for Neurosciences and Developmental Biology, University of Vienna, Vienna 1030, Austria.
  • Nyholm SV; Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, 80121 Napoli, NA, Italy.
  • McFall-Ngai MJ; Molecular Genetics Unit, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan.
  • Simakov O; Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.
iScience ; 26(7): 107091, 2023 Jul 21.
Article en En | MEDLINE | ID: mdl-37426346
Light organs (LO) with symbiotic bioluminescent bacteria are hallmarks of many bobtail squid species. These organs possess structural and functional features to modulate light, analogous to those found in coleoid eyes. Previous studies identified four transcription factors and modulators (SIX, EYA, PAX6, DAC) associated with both eyes and light organ development, suggesting co-option of a highly conserved gene regulatory network. Using available topological, open chromatin, and transcriptomic data, we explore the regulatory landscape around the four transcription factors as well as genes associated with LO and shared LO/eye expression. This analysis revealed several closely associated and putatively co-regulated genes. Comparative genomic analyses identified distinct evolutionary origins of these putative regulatory associations, with the DAC locus showing a unique topological and evolutionarily recent organization. We discuss different scenarios of modifications to genome topology and how these changes may have contributed to the evolutionary emergence of the light organ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: IScience Año: 2023 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: IScience Año: 2023 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos