Your browser doesn't support javascript.
loading
Propofol Mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.
Tauber, John M; Brincat, Scott L; Stephen, Emily P; Donaghue, Jacob A; Kozachkov, Leo; Brown, Emery N; Miller, Earl K.
Afiliación
  • Tauber JM; The Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Brincat SL; Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Stephen EP; Institute for Data, Systems, and Society, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Donaghue JA; The Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Kozachkov L; Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Brown EN; Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA.
  • Miller EK; The Picower Institute for Learning & Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
bioRxiv ; 2023 Jun 29.
Article en En | MEDLINE | ID: mdl-37425684
A critical component of anesthesia is the loss sensory perception. Propofol is the most widely used drug for general anesthesia, but the neural mechanisms of how and when it disrupts sensory processing are not fully understood. We analyzed local field potential (LFP) and spiking recorded from Utah arrays in auditory cortex, associative cortex, and cognitive cortex of non-human primates before and during propofol mediated unconsciousness. Sensory stimuli elicited robust and decodable stimulus responses and triggered periods of stimulus-induced coherence between brain areas in the LFP of awake animals. By contrast, propofol mediated unconsciousness eliminated stimulus-induced coherence and drastically weakened stimulus responses and information in all brain areas except for auditory cortex, where responses and information persisted. However, we found stimuli occurring during spiking Up states triggered weaker spiking responses than in awake animals in auditory cortex, and little or no spiking responses in higher order areas. These results suggest that propofol's effect on sensory processing is not just due to asynchronous down states. Rather, both Down states and Up states reflect disrupted dynamics.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos