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In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy.
Li, Shifen; Zhang, Hua; Xie, Jieqi; Wang, Zhaoyi; Wang, Kai; Zhai, Zihe; Ding, Jie; Wang, Shuqin; Shen, Liyin; Wen, Jun; Tang, Yi-Da; Wang, Huanan; Zhu, Yang; Gao, Changyou.
Afiliación
  • Li S; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Zhang H; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
  • Xie J; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Wang Z; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Wang K; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Zhai Z; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Ding J; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Wang S; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Shen L; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Wen J; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
  • Tang YD; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, 100191, China.
  • Wang H; College of Animal Science, Zhejiang University, Hangzhou 310058, China.
  • Zhu Y; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
  • Gao C; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, International Research Center for X Polymers, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. zhuyang@zju.edu.cn.
Mater Horiz ; 10(9): 3438-3449, 2023 08 29.
Article en En | MEDLINE | ID: mdl-37424353
Advanced elastomers are highly in demand for the fabrication of medical devices for minimally invasive surgery (MIS). Herein, a shape memory and self-healing polyurethane (PCLUSe) composed of semi-crystalline poly(ε-caprolactone) (PCL) segments and interchangeable and antioxidative diselenide bonds was designed and synthesized. The excellent shape memory of PCLUSe contributed to the smooth MIS operation, leading to less surgical wounds than in the case of sternotomy. The diselenide bonds of PCLUSe contributed to the rapid self-healing under 405 nm irradiation within 60 s, and the alleviation of tissue oxidation post injury. After being delivered through a 10 mm diameter trocar onto a beating canine heart by MIS, two shape-recovered PCLUSe films self-assembled (self-healing) into a larger single patch (20 × 10 × 0.2 mm3) under the trigger of laser irradiation in situ, which could efficiently overcome the limited-size problem within MIS and meet a larger treatment area. The diselenide bonds in the PCLUSe cardiac patches protected the myocardium under oxidative stress post myocardial infarction (MI), and significantly maintained the cardiac functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliuretanos / Infarto del Miocardio Límite: Animals Idioma: En Revista: Mater Horiz Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliuretanos / Infarto del Miocardio Límite: Animals Idioma: En Revista: Mater Horiz Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido