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Deoxyestrone-based lipofection agents with solution- and solid-state emission properties.
Huber, Alexander; Koch, Johannes; Rudolph, Kevin; Höing, Alexander; Rizzo, Fabio; Knauer, Shirley K; Voskuhl, Jens.
Afiliación
  • Huber A; Faculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45117 Essen, Germany. jens.voskuhl@uni-due.de.
  • Koch J; Center of Medical Biotechnology (ZMB), University of Duisburg Essen, Universitätsstraße 2, 45141 Essen, Germany.
  • Rudolph K; Faculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45117 Essen, Germany. jens.voskuhl@uni-due.de.
  • Höing A; Department of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg Essen, Universitätsstraße 2, 45141 Essen, Germany.
  • Rizzo F; Center for Soft Nanoscience (SoN), Westfälische Wilhelms-Universität Münster, Busso-Peus-Straße 10, 48149 Münster, Germany.
  • Knauer SK; Institute of Chemical Science and Technologies "G. Natta" (SCITEC), National Research Council (CNR), Via G. Fantoli 16/15, 20138 Milan, Italy.
  • Voskuhl J; Department of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg Essen, Universitätsstraße 2, 45141 Essen, Germany.
Org Biomol Chem ; 21(28): 5762-5767, 2023 07 19.
Article en En | MEDLINE | ID: mdl-37404013
In this contribution, three deoxyestrone-based emissive lipofection agents are reported. Because of a centrally incorporated terephthalonitrile motif, these ligands can be classified as solution and solid-state emitters (SSSEs). With the attachment of tobramycin, these amphiphilic structures are able to form lipoplexes, mediating gene transfection of HeLa and HEK 293T cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Liposomas Límite: Humans Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Liposomas Límite: Humans Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido