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Assessment of efficacy of carboxytherapy in management of skin aging through evaluation of gene expression profile: a 2-split randomized clinical trial.
Bagherani, Nooshin; Firooz, Alireza; Ghanadan, Alireza; Smoller, Bruce R; Mirmomeni, Golshan; Shojaei, Reza; Mondanizadeh, Mahdieh; Tavoosidana, Gholamreza.
Afiliación
  • Bagherani N; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Firooz A; Center for Research and Training in Skin Diseases and Leprosy, Clinical Trial Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Ghanadan A; Department of Dermatopathology, Razi Hospital, Tehran, Iran.
  • Smoller BR; Department of Pathology, Cancer Institute, Imam Khoemini Hospital Complex, Tehran, Iran.
  • Mirmomeni G; Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, USA.
  • Shojaei R; Hearing Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Mondanizadeh M; Department of Surgery, Arak University of Medical Sciences, Arak, Markazi Province, Iran.
  • Tavoosidana G; Department of Biotechnology and Molecular Medicine, Arak University of Medical Sciences, Arak, Iran.
Arch Dermatol Res ; 315(9): 2575-2584, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37402830
Skin aging is a continuous and irreversible process which results in impairment of the skin role as barrier against all aggressive exogenous factors. It mainly manifests by photoaging, laxity, sagging, wrinkling, and xerosis. Carboxytherapy is considered as a safe, minimally invasive modality used for rejuvenation, restoration, and recondition of the skin. In the current study, the efficacy of carboxytherapy in the treatment of skin aging was assessed through investigation of gene expression profile for Coll I, Coll III, Coll IV, elastin, FGF, TGF-ß1, and VEGF. Our study is a 2-split clinical trial in which carboxytherapy was performed on one side of the abdomen in 15 cases with intrinsically skin aging manifestations weekly for 10 sessions, while the other side of the abdomen was left without treatment. Two weeks after the last session, skin biopsies were taken from both the treated and control sides of the abdomen in order to assess gene expression profile by qRT-PCR. The analysis of gene expression levels for all of Coll I, Coll III, Coll IV, elastin, TGF-ß1, FGF and VEGF genes showed a statistically significant difference between the interventional and control groups. The findings for all of these seven genes showed increase in the interventional group, among which Coll IV, VEGF, FGF, and elastin showed the higher mean changes. Our study confirmed the effectiveness of carboxytherapy in treating and reversing the intrinsically aging skin.Clinical Trial Registration Code and Date of Registration: ChiCTR2200055185; 2022/1/2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Arch Dermatol Res Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento de la Piel Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Arch Dermatol Res Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Alemania