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Longevity factor klotho enhances cognition in aged nonhuman primates.
Castner, Stacy A; Gupta, Shweta; Wang, Dan; Moreno, Arturo J; Park, Cana; Chen, Chen; Poon, Yan; Groen, Aaron; Greenberg, Kenneth; David, Nathaniel; Boone, Tom; Baxter, Mark G; Williams, Graham V; Dubal, Dena B.
Afiliación
  • Castner SA; Department of Psychiatry and VA Connecticut Healthcare System, Yale School of Medicine, West Haven, CT, USA.
  • Gupta S; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
  • Wang D; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
  • Moreno AJ; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
  • Park C; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
  • Chen C; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
  • Poon Y; Unity Biotechnology, Brisbane, CA, USA.
  • Groen A; Unity Biotechnology, Brisbane, CA, USA.
  • Greenberg K; Unity Biotechnology, Brisbane, CA, USA.
  • David N; Unity Biotechnology, Brisbane, CA, USA.
  • Boone T; Tom Boone Consulting, Newbury Park, CA, USA.
  • Baxter MG; Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Williams GV; Department of Psychiatry and VA Connecticut Healthcare System, Yale School of Medicine, West Haven, CT, USA.
  • Dubal DB; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Dena.Dubal@ucsf.edu.
Nat Aging ; 3(8): 931-937, 2023 08.
Article en En | MEDLINE | ID: mdl-37400721
Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucuronidasa / Longevidad Tipo de estudio: Prognostic_studies Límite: Aged / Animals / Humans Idioma: En Revista: Nat Aging Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucuronidasa / Longevidad Tipo de estudio: Prognostic_studies Límite: Aged / Animals / Humans Idioma: En Revista: Nat Aging Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos