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SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia: A long-term study.
Xu, Ning; Li, Long-Song; Li, Hui; Zhang, Li-Hua; Zhang, Nan; Wang, Peng-Ju; Cheng, Ya-Xuan; Xiang, Jing-Yuan; Linghu, En-Qiang; Chai, Ning-Li.
Afiliación
  • Xu N; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Li LS; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Li H; Department of Gastroenterology, Air Force Medical Center, Beijing 100142, China.
  • Zhang LH; Department of Pathology, The Fourth Medical Center of PLA General Hospital, Beijing 100142, China.
  • Zhang N; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Wang PJ; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Cheng YX; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Xiang JY; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Linghu EQ; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China.
  • Chai NL; Senior Department of Gastroenterology, The First Medical Center of PLA General Hospital, Beijing 100853, China. chainingli@vip.163.com.
World J Gastroenterol ; 29(23): 3658-3667, 2023 Jun 21.
Article en En | MEDLINE | ID: mdl-37398883
BACKGROUND: The expression status of serum and glucocorticoid-induced protein kinase 3 (SGK3) in superficial esophageal squamous cell neoplasia (ESCN) remains unknown. AIM: To evaluate the SGK3 overexpression rate in ESCN and its influence on the prognosis and outcomes of patients with endoscopic resection. METHODS: A total of 92 patients who had undergone endoscopic resection for ESCN with more than 8 years of follow-up were enrolled. Immunohistochemistry was used to evaluate SGK3 expression. RESULTS: SGK3 was overexpressed in 55 (59.8%) patients with ESCN. SGK3 overexpression showed a significant correlation with death (P = 0.031). Overall survival and disease-free survival rates were higher in the normal SGK3 expression group than in the SGK3 overexpression group (P = 0.013 and P = 0.004, respectively). Cox regression analysis models demonstrated that SGK3 overexpression was an independent predictor of poor prognosis in ESCN patients (hazard ratio 4.729; 95% confidence interval: 1.042-21.458). CONCLUSION: SGK3 overexpression was detected in the majority of patients with endoscopically resected ESCN and was significantly associated with shortened survival. Thus, it might be a new prognostic factor for ESCN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: World J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: World J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos