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Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach.
Jiménez-Rodríguez, Gian-Manuel; Carmona-Levario, Patricia; Ayón-Martínez, José-Alberto; Gasecka, Aleksandra; Juárez-Orozco, Luis Eduardo; Reyes-Ortega, Antonio; Espinosa-González, Patricia; Altamirano-Solorzano, Gyna Alejandra; Eid-Lidt, Guering.
Afiliación
  • Jiménez-Rodríguez GM; Interventional Cardiology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
  • Carmona-Levario P; Interventional Cardiology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
  • Ayón-Martínez JA; Interventional Cardiology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
  • Gasecka A; Department of Cardiology of the Medical University of Warsaw Warsaw, Poland.
  • Juárez-Orozco LE; Cardiology Department, University Medical Center Utrecht Utrecht, the Netherlands.
  • Reyes-Ortega A; Cardiology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
  • Espinosa-González P; Cardiology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
  • Altamirano-Solorzano GA; Haematology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
  • Eid-Lidt G; Interventional Cardiology Department, National Institute of Cardiology Ignacio Chávez Mexico City, Mexico.
Interv Cardiol ; 18: e15, 2023.
Article en En | MEDLINE | ID: mdl-37398876
Glycoprotein IIb/IIIa inhibitors are an adjuvant therapy for the treatment of patients with acute coronary syndromes. The main adverse reactions are bleeding and thrombocytopenia in 1-2% of cases. A 66-year-old woman arrived at the emergency department with ST-elevation MI. The catheterisation lab was busy, so she received thrombolytic therapy. Coronary angiography revealed a 90% stenosis in the middle segment of the left anterior descending artery and Thrombolysis in MI 2 flow. Subsequent percutaneous coronary intervention showed abundant thrombus and a coronary dissection and it was necessary to insert five drug-eluting stents. Non-fractionated heparin and a tirofiban infusion were used. After the percutaneous coronary intervention, she developed severe thrombocytopenia, haematuria and gingivorrhagia, for which infusion of tirofiban was suspended. In follow-up, no major bleeding or subsequent haemorrhagic complications were identified. It is crucial to distinguish between heparin-induced thrombocytopenia and thrombocytopenia caused by other drugs. A high level of suspicion should be employed in these cases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Interv Cardiol Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Interv Cardiol Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido