Accelerated export of Dicer1 from lipid-challenged hepatocytes buffers cellular miRNA-122 levels and prevents cell death.

Bandyopadhyay, Diptankar; Basu, Sudarshana; Mukherjee, Ishita; Chakrabarti, Saikat; Chakrabarti, Partha; Mukherjee, Kamalika; Bhattacharyya, Suvendra N

Bandyopadhyay, Diptankar; Basu, Sudarshana; Mukherjee, Ishita; Chakrabarti, Saikat; Chakrabarti, Partha; Mukherjee, Kamalika; Bhattacharyya, Suvendra N.

Afiliación

Bandyopadhyay D; RNA Biology Research Laboratory, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Basu S; RNA Biology Research Laboratory, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India; Department of Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute (NCRI) Kolkata, India.
Mukherjee I; Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Chakrabarti S; Structural Biology and Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Chakrabarti P; Metabolic Disease Laboratory, Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Mukherjee K; RNA Biology Research Laboratory, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA.
Bhattacharyya SN; RNA Biology Research Laboratory, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA. Electronic address: suvendra@iicb.res.in.

J Biol Chem ; 299(8): 104999, 2023 08.

Article en En | MEDLINE | ID: mdl-37394005

Asunto(s)

MicroARNs; Animales; Ratones; Muerte Celular; ARN Helicasas DEAD-box/metabolismo; Dieta Alta en Grasa; Hepatocitos/metabolismo; Lípidos; Mamíferos/metabolismo; MicroARNs/genética; MicroARNs/metabolismo; Ribonucleasa III/genética; Ratones Endogámicos C57BL; Humanos; Masculino; Línea Celular Tumoral

Palabras clave

Dicer1; cell death; extracellular vesicles; lipotoxic stress; miRNA

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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