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Magnetic Resonance Diffusion Tensor Imaging Characterize the Hepatic Ischemia-Reperfusion Injury in an Animal Study.
Liu, Minglu; Zhang, Cheng; Shen, Sandi; Shao, Jiakang; Wang, Ying; Jiao, Shunchang; Guo, Chengwei.
Afiliación
  • Liu M; Department of Medical Oncology, the First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, China; Outpatient Department, Jingnan Medical Area, Chinese People's Liberation Army General Hospital, Beijing, China.
  • Zhang C; Outpatient Department, Jingnan Medical Area, Chinese People's Liberation Army General Hospital, Beijing, China.
  • Shen S; Thoracic Surgery, the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
  • Shao J; Medical School of Chinese People's Liberation Army, Beijing, China.
  • Wang Y; Outpatient Department, Jingnan Medical Area, Chinese People's Liberation Army General Hospital, Beijing, China.
  • Jiao S; Department of Medical Oncology, the First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address: 121641120@qq.com.
  • Guo C; Department of Radiology, 82 Group Hospital of Chinese People's Liberation Army, Baoding, China. Electronic address: gcw323765@163.com.
Transplant Proc ; 55(7): 1739-1746, 2023 Sep.
Article en En | MEDLINE | ID: mdl-37393167
BACKGROUND: Hepatic ischemia-reperfusion (I/R) injury is the main cause of morbidity and mortality after hepatectomy; thus, new methods for reducing I/R injury are required. The aim of this study is to evaluate changes in the average apparent diffusion coefficient (ADCavg) and fractional anisotropy (FA) in rabbits with partial hepatic I/R injury with magnetic resonance diffusion tensor imaging (DTI). METHODS: The left lobe of the rabbit liver underwent 60 minutes of ischemia followed by 0.5, 2, 6, 12, 24, and 48 hours of reperfusion. T2-weighted images (T2WI), T1-weighted images (T1WI), DTI, and contrast-enhanced T1WI were performed; 6 b values were used for DTI on 6 diffusion directions. The serum levels of transaminases and liver histopathology findings were examined. RESULTS: In the early stage of I/R (0.5 hour), ADCavg decreased significantly and increased sharply to 2 hours, then increased from 6 hours to 48 hours of reperfusion, except for a transient decrease (24 hours). Meanwhile, FA showed almost the opposite trend, drastically increasing during the first 0.5 hour and then slightly decreasing until 48 hours of reperfusion, except for an obvious decrease in the 2-hours group. The serum levels of liver markers and the pathologic scores were sharply increased in the I/R group after reperfusion and correlated with DTI of hepatic tissue after I/R. CONCLUSIONS: Diffusion tensor imaging is feasible for imaging I/R-induced liver damage and can discriminate isotropic properties of the liver after I/R injury with objective changes in the ADCavg and FA. Diffusion tensor imaging can be a promising novel approach for use in clinical management after liver surgery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Imagen de Difusión Tensora Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Transplant Proc Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Imagen de Difusión Tensora Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Transplant Proc Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos