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Dentate Gyrus Microstructure Is Associated With Resilience After Exposure to Maternal Stress Across Two Human Cohorts.
van Dijk, Milenna T; Talati, Ardesheer; Kashyap, Pratik; Desai, Karan; Kelsall, Nora C; Gameroff, Marc J; Aw, Natalie; Abraham, Eyal; Cullen, Breda; Cha, Jiook; Anacker, Christoph; Weissman, Myrna M; Posner, Jonathan.
Afiliación
  • van Dijk MT; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
  • Talati A; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
  • Kashyap P; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina.
  • Desai K; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina.
  • Kelsall NC; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
  • Gameroff MJ; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York.
  • Aw N; Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland.
  • Abraham E; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, New York.
  • Cullen B; School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
  • Cha J; Department of Psychology, Seoul National University, Seoul, Republic of Korea.
  • Anacker C; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Systems Neuroscience, New York State Psychiatric Institute, New York, New York; Columbia University Institute for Developmental Sciences, New York, New York.
  • Weissman MM; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York; Columbia University Institute for Developmental Sciences, New York, New York; Department of
  • Posner J; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina.
Biol Psychiatry ; 95(1): 27-36, 2024 Jan 01.
Article en En | MEDLINE | ID: mdl-37393047
ABSTRACT

BACKGROUND:

Maternal stress (MS) is a well-documented risk factor for impaired emotional development in offspring. Rodent models implicate the dentate gyrus (DG) of the hippocampus in the effects of MS on offspring depressive-like behaviors, but mechanisms in humans remain unclear. Here, we tested whether MS was associated with depressive symptoms and DG micro- and macrostructural alterations in offspring across 2 independent cohorts.

METHODS:

We analyzed DG diffusion tensor imaging-derived mean diffusivity (DG-MD) and volume in a three-generation family risk for depression study (TGS; n = 69, mean age = 35.0 years) and in the Adolescent Brain Cognitive Development (ABCD) Study (n = 5196, mean age = 9.9 years) using generalized estimating equation models and mediation analysis. MS was assessed by the Parenting Stress Index (TGS) and a measure compiled from the Adult Response Survey from the ABCD Study. The Patient Health Questionnaire-9 and rumination scales (TGS) and the Child Behavior Checklist (ABCD Study) measured offspring depressive symptoms at follow-up. The Schedule for Affective Disorders and Schizophrenia-Lifetime interview was used to assign depression diagnoses.

RESULTS:

Across cohorts, MS was associated with future symptoms and higher DG-MD (indicating disrupted microstructure) in offspring. Higher DG-MD was associated with higher symptom scores measured 5 years (in the TGS) and 1 year (in the ABCD Study) after magnetic resonance imaging. In the ABCD Study, DG-MD was increased in high-MS offspring who had depressive symptoms at follow-up, but not in offspring who remained resilient or whose mother had low MS.

CONCLUSIONS:

Converging results across 2 independent samples extend previous rodent studies and suggest a role for the DG in exposure to MS and offspring depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen de Difusión Tensora / Madres Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans Idioma: En Revista: Biol Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen de Difusión Tensora / Madres Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans Idioma: En Revista: Biol Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos