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Patterns of treatment failure in patients with nasopharyngeal carcinoma and salvage treatment outcome: A retrospective analysis study.
Aldhahri, Saleh F; Barakeh, Maha M; Almetary, Rakan J; Alfirm, Renad B; Almousa, Hisham M; Alsubaie, Hemail M.
Afiliación
  • Aldhahri SF; Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Department of Otolaryngology-Head and Neck Surgery, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address: saldhahri@ksu.edu.sa.
  • Barakeh MM; College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Almetary RJ; College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alfirm RB; College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Almousa HM; College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alsubaie HM; Department of Otolaryngology-Head and Neck Surgery, King Abdullah Medical City, Makkah, Saudi Arabia.
Am J Otolaryngol ; 44(5): 103941, 2023.
Article en En | MEDLINE | ID: mdl-37392726
INTRODUCTION: In Saudi Arabia, head and neck cancers represent 6 % of all malignancies. 33 % of these are nasopharyngeal. Thus, we aimed to distinguish patterns of treatment failure and salvage treatment outcomes among patients with nasopharyngeal carcinoma (NPC). METHODS: A retrospective review of patients treated for NPC in a tertiary care hospital. From May 2012 to January 2020, we retrospectively reviewed 175 patients that fit our inclusion criteria. Those who did not complete their treatment, started treatment in another institution, or did not complete a 3-year follow-up were excluded. In addition, the primary treatment outcome and the salvage treatment for those who failed initial treatment were collected and analyzed. RESULTS: Patients were predominantly stage 4 disease. 67 % of the patients were alive without evidence of disease during their last follow-up. However, 75 % of failure occurs in the first 20 months of completing the treatment regimen. Neoadjuvant therapy and delays in referral play a significant role in treatment failure. For failed cases, concurrent salvage chemoradiotherapy showed the best survival. CONCLUSION: Advanced stage 4A and T4 nasopharyngeal carcinoma should receive the maximum treatment, with a close follow-up, particularly during the first 2 years after treatment. Furthermore, the excellent outcome from salvage chemoradiotherapy and radiotherapy alone would make physicians aware of the importance of aggressive primary treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Nasofaríngeas / Terapia Recuperativa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Otolaryngol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Nasofaríngeas / Terapia Recuperativa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Otolaryngol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos