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Three-dimensional histological electrophoresis enables fast automatic distinguishment of cancer margins and lymph node metastases.
Zhang, Feiran; Xu, Jiajun; Yue, Ying; Wang, Yajun; Sun, Jianing; Song, Dong; Zhang, Chengbin; Qu, Limei; Zhu, Shoujun; Zhang, Junhu; Yang, Bai.
Afiliación
  • Zhang F; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
  • Xu J; Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, P. R. China.
  • Yue Y; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
  • Wang Y; Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, P. R. China.
  • Sun J; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
  • Song D; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun 130012, P. R. China.
  • Zhang C; Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun 130021, P. R. China.
  • Qu L; School of Mathematics and Statistics, Northeast Normal University, Changchun 130024, P. R. China.
  • Zhu S; Department of Breast Surgery, The First Hospital of Jilin University, Changchun 130021, P. R. China.
  • Zhang J; Department of Pathology, The First Hospital of Jilin University, Changchun 130021, P. R. China.
  • Yang B; Department of Pathology, The First Hospital of Jilin University, Changchun 130021, P. R. China.
Sci Adv ; 9(26): eadg2690, 2023 06 30.
Article en En | MEDLINE | ID: mdl-37390200
Tissue diagnosis is important during surgical excision of solid tumors for margin evaluation. Conventional histopathologic methods rely heavily on image-based visual diagnosis by specialized pathologists, which can be time-consuming and subjective. We report a three-dimensional (3D) histological electrophoresis system for rapid labeling and separation of the proteins within tissue sections, providing a more precise assessment of tumor-positive margin in surgically resected tissues. The 3D histological electrophoresis system uses a tumor-seeking dye labeling strategy to visualize the distribution of tumor-specific proteins within sections and a tumor finder that automatically predicts the tumor contour. We successfully demonstrated the system's capability to predict the tumor contours from five murine xenograft models and distinguish the tumor-invaded region of sentinel lymph nodes. Specifically, we used the system to accurately assess tumor-positive margins from 14 patients with cancer. Our 3D histological electrophoresis system serves as an intraoperative tissue assessment technology for more accurate and automatic pathologic diagnosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tecnología / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tecnología / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos