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Smoking, early menopause and multiple sclerosis disease course.
Neyal, Nur; Atkinson, Elizabeth J; Smith, Carin Y; Weis, Delana M; Gazzuola Rocca, Liliana; Rocca, Walter A; Kantarci, Kejal; Kantarci, Orhun H; Zeydan, Burcu.
Afiliación
  • Neyal N; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Atkinson EJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
  • Smith CY; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
  • Weis DM; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
  • Gazzuola Rocca L; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
  • Rocca WA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
  • Kantarci K; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Kantarci OH; Women's Health Research Center, Mayo Clinic, Rochester, MN, USA.
  • Zeydan B; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Climacteric ; 26(6): 560-564, 2023 12.
Article en En | MEDLINE | ID: mdl-37387356
Smoking is associated with an increased risk of multiple sclerosis (MS), and smoking and early menopause are related to poor outcomes in MS. Smoking is also associated with early menopause. To explore this intricate relationship between smoking status, age at menopause and disease course in MS, 137 women with MS and 396 age-matched controls were included in this case-control study. Age at menopause (median 49.0 vs. 50.0 years; p = 0.79) and smoking status (40.3% vs. 47.6%; p = 0.15) were similar among MS and control women. Relapsing MS onset was earlier in ever-smoker women with early menopause compared to the rest of the women (median 30.4 vs. 37.0 years; p = 0.02) and also compared to ever-smoker women with normal age at menopause (median 30.4 vs. 41.0 years; p = 0.008) and never-smoker women with early menopause (median 30.4 vs. 41.5 years; p = 0.004). Progressive MS onset was also earlier in ever-smoker women with early menopause compared to ever-smoker women with normal age at menopause (median 41.1 vs. 49.4 years; p = 0.05) and never-smoker women with early menopause (median 41.1 vs. 50.1 years; p = 0.12). Our results suggest that smoking and menopause associate with MS disease course, including the onset of relapsing and progressive MS in women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Menopausia Prematura / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Climacteric Asunto de la revista: GINECOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Menopausia Prematura / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Climacteric Asunto de la revista: GINECOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido