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Design of silicone interfaces with antibacterial properties.
Barshutina, Marie; Yakubovsky, Dmitry; Kirtaev, Roman; Volkov, Valentyn; Arsenin, Aleksey; Vladimirova, Anastasiya; Baymiev, Andrei; Barshutin, Sergey.
Afiliación
  • Barshutina M; Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
  • Yakubovsky D; Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
  • Kirtaev R; Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
  • Volkov V; Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
  • Arsenin A; Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
  • Vladimirova A; Institute of Biochemistry and Genetics, Subdivision of the Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia.
  • Baymiev A; Institute of Biochemistry and Genetics, Subdivision of the Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia.
  • Barshutin S; Institute of Power Engineering, Instrument Engineering, and Electronics, Tambov State Technical University, Tambov, Russia.
Biofouling ; 39(5): 473-482, 2023.
Article en En | MEDLINE | ID: mdl-37386940
Silicone implants are widely used for plastic or reconstruction medical applications. However, they can cause severe infections of inner tissues due to bacterial adhesion and biofilm growth on implant surfaces. The development of new antibacterial nanostructured surfaces can be considered as the most promising strategy to deal with this problem. In this article, we studied the influence of nanostructuring parameters on the antibacterial properties of silicone surfaces. Nanostructured silicone substrates with nanopillars of various dimensions were fabricated using a simple soft lithography technique. Upon testing of the obtained substrates, we identified the optimal parameters of silicone nanostructures to achieve the most pronounced antibacterial effect against the bacterial culture of Escherichia coli. It was demonstrated that up to 90% reduction in bacterial population compared to flat silicone substrates can be achieved. We also discussed possible underlying mechanisms behind the observed antibacterial effect, the understanding of which is essential for further progress in this field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopelículas / Nanoestructuras Idioma: En Revista: Biofouling Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biopelículas / Nanoestructuras Idioma: En Revista: Biofouling Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido