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A Study of Physical Resilience and Aging (SPRING): Conceptual framework, rationale, and study design.
Walston, Jeremy; Varadhan, Ravi; Xue, Qian-Li; Buta, Brian; Sieber, Frederick; Oni, Julius; Imus, Phil; Crews, Deidra C; Artz, Andrew; Schrack, Jennifer; Kalyani, Rita R; Abadir, Peter; Carlson, Michelle; Hladek, Melissa; McAdams-DeMarco, Mara; Jones, Rick; Johnson, Aaron; Shafi, Tariq; Newman, Anne B; Bandeen-Roche, Karen.
Afiliación
  • Walston J; Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Varadhan R; Johns Hopkins School of Nursing, Baltimore, Maryland, USA.
  • Xue QL; Department of Oncology, Division of Quantitative Sciences, Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.
  • Buta B; Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sieber F; Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Oni J; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA.
  • Imus P; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Crews DC; Department of Oncology, Division of Hematologic Malignancy, Johns Hopkins Hospital/Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA.
  • Artz A; Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Schrack J; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA.
  • Kalyani RR; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Abadir P; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Carlson M; Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hladek M; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • McAdams-DeMarco M; Johns Hopkins School of Nursing, Baltimore, Maryland, USA.
  • Jones R; Department of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
  • Johnson A; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Shafi T; Department of Orthopaedics, University of Maryland, Baltimore, Maryland, USA.
  • Newman AB; Division of Nephrology, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA.
  • Bandeen-Roche K; Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Am Geriatr Soc ; 71(8): 2393-2405, 2023 08.
Article en En | MEDLINE | ID: mdl-37386913
Understanding the physiological basis of physical resilience to clinical stressors is crucial for the well-being of older adults. This article presents a novel framework to discover the biological underpinnings of physical resilience in older adults as part of the "Characterizing Resiliencies to Physical Stressors in Older Adults: A Dynamical Physiological Systems Approach" study, also known as The Study of Physical Resilience and Aging (SPRING). Physical resilience, defined as the capacity of a person to withstand clinical stressors and quickly recover or improve upon a baseline functional level, is examined in adults aged 55 years and older by studying the dynamics of stress response systems. The hypothesis is that well-regulated stress response systems promote physical resilience. The study employs dynamic stimulation tests to assess energy metabolism, the hypothalamic-pituitary-adrenal axis, the autonomic nervous system, and the innate immune system. Baseline characteristics influencing resilience outcomes are identified through deep phenotyping of physical and cognitive function, as well as of biological, environmental, and psychosocial characteristics. SPRING aims to study participants undergoing knee replacement surgery (n = 100), bone and marrow transplantation (n = 100), or anticipating dialysis initiation (n = 60). Phenotypic and functional measures are collected pre-stressor and at multiple times after stressor for up to 12 months to examine resilience trajectories. By improving our understanding of physical resilience in older adults, SPRING has the potential to enhance resilient outcomes to major clinical stressors. The article provides an overview of the study's background, rationale, design, pilot phase, implementation, and implications for improving the health and well-being of older adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resiliencia Psicológica Tipo de estudio: Prognostic_studies Límite: Aged / Humans Idioma: En Revista: J Am Geriatr Soc Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resiliencia Psicológica Tipo de estudio: Prognostic_studies Límite: Aged / Humans Idioma: En Revista: J Am Geriatr Soc Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos