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Peripheral T-cell lymphoma with a T follicular-helper phenotype: A different entity? Results of the Spanish Real-T study.
Martín García-Sancho, Alejandro; Rodríguez-Pinilla, Socorro M; Domingo-Domenech, Eva; Climent, Fina; Sánchez-Garcia, Joaquín; López Jiménez, Javier; García-Cosío Piqueras, Mónica; Castellvi, Josep; González, Ana Julia; González de Villambrosia, Sonia; Gómez Codina, José; Navarro, Belén; Rodríguez, Guillermo; Borrero, Juan José; Fraga, Máximo; Naves, Andrea; Baeza, Lourdes; Córdoba, Raúl.
Afiliación
  • Martín García-Sancho A; Department of Hematology, University Hospital of Salamanca (HUS/IBSAL), CIBERONC, University of Salamanca and Cancer Research Institute of Salamanca-IBMCC (USAL-CSIC), Salamanca, Spain.
  • Rodríguez-Pinilla SM; Pathology Department, Hospital Universitario Fundación Jiménez Díaz, CIBERONC, Madrid, Spain.
  • Domingo-Domenech E; Hematology Department, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Spain.
  • Climent F; Pathology Department, Hospital Universitari de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Spain.
  • Sánchez-Garcia J; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Hematology Department, Hospital Universitario Reina Sofía, Córdoba, Spain.
  • López Jiménez J; Hematology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • García-Cosío Piqueras M; Anatomical Pathology Department, Hospital Universitario Ramón y Cajal, CIBERONC, Madrid, Spain.
  • Castellvi J; Department of Pathology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • González AJ; Hematology Department, Hospital Universitario Central de Asturias, Oviedo, Spain.
  • González de Villambrosia S; Hematology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Gómez Codina J; Medical Oncology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Navarro B; Hematology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
  • Rodríguez G; Hematology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
  • Borrero JJ; Anatomical Pathology Department, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/Universidad de Sevilla, Sevilla, Spain.
  • Fraga M; Pathology Department, Hospital Clínico Universitario Santiago, Santiago de Compostela, Spain.
  • Naves A; Medical Department, Takeda Farmacéutica España S.A., Madrid, Spain.
  • Baeza L; Medical Department, Takeda Farmacéutica España S.A., Madrid, Spain.
  • Córdoba R; Hematology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
Br J Haematol ; 203(2): 182-193, 2023 10.
Article en En | MEDLINE | ID: mdl-37386897
Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7-73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T Periférico / Linfadenopatía Inmunoblástica Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Br J Haematol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T Periférico / Linfadenopatía Inmunoblástica Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Br J Haematol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido