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Immunological imprinting of humoral immunity to SARS-CoV-2 in children.
Dowell, Alexander C; Lancaster, Tara; Bruton, Rachel; Ireland, Georgina; Bentley, Christopher; Sylla, Panagiota; Zuo, Jianmin; Scott, Sam; Jadir, Azar; Begum, Jusnara; Roberts, Thomas; Stephens, Christine; Ditta, Shabana; Shepherdson, Rebecca; Powell, Annabel A; Brent, Andrew J; Brent, Bernadette; Baawuah, Frances; Okike, Ifeanyichukwu; Beckmann, Joanne; Ahmad, Shazaad; Aiano, Felicity; Garstang, Joanna; Ramsay, Mary E; Azad, Rafaq; Waiblinger, Dagmar; Willett, Brian; Wright, John; Ladhani, Shamez N; Moss, Paul.
Afiliación
  • Dowell AC; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Lancaster T; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Bruton R; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Ireland G; Immunisation Department, UK Health Security Agency, 61 Colindale Avenue, London, UK.
  • Bentley C; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Sylla P; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Zuo J; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Scott S; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Jadir A; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Begum J; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Roberts T; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Stephens C; Institute of Immunology & Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
  • Ditta S; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
  • Shepherdson R; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
  • Powell AA; Immunisation Department, UK Health Security Agency, 61 Colindale Avenue, London, UK.
  • Brent AJ; Oxford University Hospitals NHS Foundation Trust, Old Road, Oxford, UK.
  • Brent B; University of Oxford, Wellington Square, Oxford, OX1 2JD, UK.
  • Baawuah F; Oxford University Hospitals NHS Foundation Trust, Old Road, Oxford, UK.
  • Okike I; Immunisation Department, UK Health Security Agency, 61 Colindale Avenue, London, UK.
  • Beckmann J; Immunisation Department, UK Health Security Agency, 61 Colindale Avenue, London, UK.
  • Ahmad S; University Hospitals of Derby and Burton NHS Foundation Trust, Uttoxeter New Road, Derby, UK.
  • Aiano F; East London NHS Foundation Trust, 9 Allie Street, London, UK.
  • Garstang J; Manchester University NHS Foundation Trust, Oxford Road, Manchester, UK.
  • Ramsay ME; Immunisation Department, UK Health Security Agency, 61 Colindale Avenue, London, UK.
  • Azad R; Birmingham Community Healthcare NHS Trust, Holt Street, Aston, UK.
  • Waiblinger D; Immunisation Department, UK Health Security Agency, 61 Colindale Avenue, London, UK.
  • Willett B; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
  • Wright J; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
  • Ladhani SN; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Moss P; Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
Nat Commun ; 14(1): 3845, 2023 06 29.
Article en En | MEDLINE | ID: mdl-37386081
Omicron variants of SARS-CoV-2 are globally dominant and infection rates are very high in children. We measure immune responses following Omicron BA.1/2 infection in children aged 6-14 years and relate this to prior and subsequent SARS-CoV-2 infection or vaccination. Primary Omicron infection elicits a weak antibody response with poor functional neutralizing antibodies. Subsequent Omicron reinfection or COVID-19 vaccination elicits increased antibody titres with broad neutralisation of Omicron subvariants. Prior pre-Omicron SARS-CoV-2 virus infection or vaccination primes for robust antibody responses following Omicron infection but these remain primarily focussed against ancestral variants. Primary Omicron infection thus elicits a weak antibody response in children which is boosted after reinfection or vaccination. Cellular responses are robust and broadly equivalent in all groups, providing protection against severe disease irrespective of SARS-CoV-2 variant. Immunological imprinting is likely to act as an important determinant of long-term humoral immunity, the future clinical importance of which is unknown.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunidad Humoral / COVID-19 Límite: Child / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunidad Humoral / COVID-19 Límite: Child / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido