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Immunomodulatory response in an experimental model of brain death.
Santana, Alexandre Chagas; Andraus, Wellington; Zimelewicz Oberman, Dan; Rabelo, Nícollas Nunes; Silva, Filipe Miranda Oliveira; Dellê, Humberto; Pepineli, Rafael; de Moraes, Edvaldo Leal; Scavone, Cristoforo; de Sá Lima, Larissa; Degaspari, Sabrina; Brasil, Sérgio; Solla, Davi Jorge Fontoura; Ruiz, Liliane Moreira; de Oliveira-Braga, Karina Andrighetti; Nepomuceno, Natalia Aparecida; Pêgo-Fernandes, Paulo Manuel; Tullius, Stefan Gunther; Figueiredo, Eberval Gadelha.
Afiliación
  • Santana AC; Neurological Surgery Department, University of Sao Paulo School of Medicine, Av. Dr. Enéas Carvalho de Aguiar, 255, 5Th Floor, São Paulo, CEP 05402-000, Brazil.
  • Andraus W; Organ Procurement Organization Department, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • Zimelewicz Oberman D; Gastroenterology Department, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Rabelo NN; Department of Neurosurgery, Hospital de Forca Aerea Do Galeão, Rio de Janeiro, Brazil.
  • Silva FMO; Neurological Surgery Department, University of Sao Paulo School of Medicine, Av. Dr. Enéas Carvalho de Aguiar, 255, 5Th Floor, São Paulo, CEP 05402-000, Brazil.
  • Dellê H; Medical Science Department, Nove de Julho University, São Paulo, Brazil.
  • Pepineli R; Medical Science Department, Nove de Julho University, São Paulo, Brazil.
  • de Moraes EL; Medical Science Department, Nove de Julho University, São Paulo, Brazil.
  • Scavone C; Organ Procurement Organization Department, School of Medicine, University of São Paulo, São Paulo, Brazil.
  • de Sá Lima L; Molecular Neuropharmacology Laboratory, Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, São Paulo, Brazil.
  • Degaspari S; Molecular Neuropharmacology Laboratory, Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, São Paulo, Brazil.
  • Brasil S; Molecular Neuropharmacology Laboratory, Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, São Paulo, Brazil.
  • Solla DJF; Neurological Surgery Department, University of Sao Paulo School of Medicine, Av. Dr. Enéas Carvalho de Aguiar, 255, 5Th Floor, São Paulo, CEP 05402-000, Brazil.
  • Ruiz LM; Neurological Surgery Department, University of Sao Paulo School of Medicine, Av. Dr. Enéas Carvalho de Aguiar, 255, 5Th Floor, São Paulo, CEP 05402-000, Brazil.
  • de Oliveira-Braga KA; Molecular Neuropharmacology Laboratory, Department of Pharmacology, Institute of Biomedical Science, University of Sao Paulo, São Paulo, Brazil.
  • Nepomuceno NA; Cardiopneumology Department, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Pêgo-Fernandes PM; Cardiopneumology Department, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Tullius SG; Cardiopneumology Department, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Figueiredo EG; Department of Surgery, Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sci Rep ; 13(1): 10524, 2023 06 29.
Article en En | MEDLINE | ID: mdl-37386074
Liver transplantation has come a long way and is now regarded as the gold standard treatment for end-stage liver failure. The great majority of livers utilized in transplantation come from brain-dead donors. A broad inflammatory response characterizes BD, resulting in multiorgan damage. This process is primarily mediated by cytokines, which increase the immunogenicity of the graft. In male Lewis rats, we evaluated the immune response in a BD liver donor and compared it to that of a control group. We studied two groups: Control and BD (rats subjected to BD by increasing intracranial pressure). After the induction of BD, there was an intense rise in blood pressure followed by a fall. There were no significant differences observed between the groups. Blood tissue and hepatic tissue analyzes showed an increase in plasma concentrations of liver enzymes (AST, ALT, LDH and ALP), in addition to pro-inflammatory cytokines and macrophages in liver tissue in animals submitted to BD. The current study found that BD is a multifaceted process that elicits both a systemic immune response and a local inflammatory response in liver tissue. Our findings strongly suggested that the immunogenicity of plasma and liver increased with time following BD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Muerte Encefálica / Enfermedad Hepática en Estado Terminal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Muerte Encefálica / Enfermedad Hepática en Estado Terminal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido