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The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.
Limoli, Charles L; Kramár, Eniko A; Almeida, Aymeric; Petit, Benoit; Grilj, Veljko; Baulch, Janet E; Ballesteros-Zebadua, Paola; Loo, Billy W; Wood, Marcelo A; Vozenin, Marie-Catherine.
Afiliación
  • Limoli CL; Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA. Electronic address: climoli@uci.edu.
  • Kramár EA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
  • Almeida A; Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
  • Petit B; Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
  • Grilj V; Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
  • Baulch JE; Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.
  • Ballesteros-Zebadua P; Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland; Laboratorio de Fisica Medica, Instituto Nacional de Neurología y Neurocirugía MVS, México City 14269, Mexico.
  • Loo BW; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Wood MA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
  • Vozenin MC; Laboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.
Radiother Oncol ; 186: 109767, 2023 09.
Article en En | MEDLINE | ID: mdl-37385377
Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciación a Largo Plazo / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Radiother Oncol Año: 2023 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciación a Largo Plazo / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Radiother Oncol Año: 2023 Tipo del documento: Article Pais de publicación: Irlanda